Cellular and molecular mechanisms regulating neuronal growth by brain‐derived neurotrophic factor
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- Andres Gonzalez
- MINREB and Center for Ageing and Regeneration (CARE UC), Faculty of Biological Sciences, Department of Physiology, Pontificia Universidad Católica de Chile Santiago Chile
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- Guillermo Moya‐Alvarado
- MINREB and Center for Ageing and Regeneration (CARE UC), Faculty of Biological Sciences, Department of Physiology, Pontificia Universidad Católica de Chile Santiago Chile
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- Christian Gonzalez‐Billaut
- Laboratory of Cell and Neuronal Dynamics, Department of Biology, Faculty of Sciences, Universidad de Chile and Geroscience Center for Brain Health and Metabolism Santiago Chile
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- Francisca C. Bronfman
- MINREB and Center for Ageing and Regeneration (CARE UC), Faculty of Biological Sciences, Department of Physiology, Pontificia Universidad Católica de Chile Santiago Chile
Abstract
<jats:p>Brain‐derived neurotrophic factor (BDNF) and its receptors TrkB and p75 regulate dendritic and axonal growth during development and maintenance of the mature nervous system; however, the cellular and molecular mechanisms underlying this process are not fully understood. In recent years, several advances have shed new light on the processes behind the regulation of BDNF‐mediated structural plasticity including control of neuronal transcription, local translation of proteins, and regulation of cytoskeleton and membrane dynamics. In this review, we summarize recent advances in the field of BDNF signaling in neurons to induce neuronal growth. © 2016 Wiley Periodicals, Inc.</jats:p>
Journal
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- Cytoskeleton
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Cytoskeleton 73 (10), 612-628, 2016-06-13
Wiley
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Details 詳細情報について
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- CRID
- 1361137043478124032
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- DOI
- 10.1002/cm.21312
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- ISSN
- 19493592
- 19493584
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- Data Source
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- Crossref