Induction of Gene Expression in <b> <i>Escherichia coli</i> </b> After Pilus-Mediated Adherence
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- Jian Ping Zhang
- J. P. Zhang, Department of Molecular Microbiology, Washington University School of Medicine, 666 South Euclid Avenue, St. Louis, MO 63110-1093, USA.
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- Staffan Normark
- S. Normark, Department of Molecular Microbiology, Washington University School of Medicine, 666 South Euclid Avenue, St. Louis, MO 63110-1093, USA, and Microbiology and Tumorbiology Center, Karolinska Institute, Box 1041, and Swedish Institute for Infectious Disease Control, S10521 Stockholm, Sweden.
説明
<jats:p> The induction of cascades of virulence factors after contact between bacteria and host cells was investigated. P-pili mediate the binding of uropathogenic <jats:italic>Escherichia coli</jats:italic> to its host cell receptor. After P-pili binding there was transcriptional activation of a sensor-regulator protein that is essential for the bacterial iron-starvation response. An insertion mutation of the sensor-regulator gene eliminated the ability of uropathogenic <jats:italic>E. coli</jats:italic> to produce siderophores and their iron-regulated membrane receptors, thereby abolishing their ability to grow in urine. These results suggest that P-pilus-mediated attachment may be an important part of the sensor-regulatory process involved in uropathogenic <jats:italic>E. coli</jats:italic> urinary tract infection. </jats:p>
収録刊行物
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- Science
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Science 273 (5279), 1234-1236, 1996-08-30
American Association for the Advancement of Science (AAAS)
