Cognitive Impairment and Risk of Stroke
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- Somayeh Rostamian
- From the Departments of Gerontology and Geriatrics (S.R., S.M., B.S., A.J.M.d.C.), Radiology (S.R., B.S.), and Medical Statistics and Bioinformatics (T.S.), Leiden University Medical Centre, Leiden, the Netherlands; and Netherlands Consortium for Healthy Ageing, Leiden, the Netherlands (A.J.M.d.C.).
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- Simin Mahinrad
- From the Departments of Gerontology and Geriatrics (S.R., S.M., B.S., A.J.M.d.C.), Radiology (S.R., B.S.), and Medical Statistics and Bioinformatics (T.S.), Leiden University Medical Centre, Leiden, the Netherlands; and Netherlands Consortium for Healthy Ageing, Leiden, the Netherlands (A.J.M.d.C.).
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- Theo Stijnen
- From the Departments of Gerontology and Geriatrics (S.R., S.M., B.S., A.J.M.d.C.), Radiology (S.R., B.S.), and Medical Statistics and Bioinformatics (T.S.), Leiden University Medical Centre, Leiden, the Netherlands; and Netherlands Consortium for Healthy Ageing, Leiden, the Netherlands (A.J.M.d.C.).
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- Behnam Sabayan
- From the Departments of Gerontology and Geriatrics (S.R., S.M., B.S., A.J.M.d.C.), Radiology (S.R., B.S.), and Medical Statistics and Bioinformatics (T.S.), Leiden University Medical Centre, Leiden, the Netherlands; and Netherlands Consortium for Healthy Ageing, Leiden, the Netherlands (A.J.M.d.C.).
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- Anton J.M. de Craen
- From the Departments of Gerontology and Geriatrics (S.R., S.M., B.S., A.J.M.d.C.), Radiology (S.R., B.S.), and Medical Statistics and Bioinformatics (T.S.), Leiden University Medical Centre, Leiden, the Netherlands; and Netherlands Consortium for Healthy Ageing, Leiden, the Netherlands (A.J.M.d.C.).
Bibliographic Information
- Other Title
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- A Systematic Review and Meta-Analysis of Prospective Cohort Studies
Abstract
<jats:sec> <jats:title>Background and Purpose—</jats:title> <jats:p>Cognitive impairment is linked to vascular risk factors and brain vascular pathologies. Several studies have tested whether subjects with cognitive impairment have higher risk for stroke. The aim of this study was to systematically review available evidence on the association between cognitive impairment and risk of stroke to obtain precise effect estimates of the association and to identify which cognitive domains associate most with incident stroke.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods—</jats:title> <jats:p>PubMed, EMBASE, and Web of Science were searched from January 1, 1980, to October 1, 2013, without language restriction. Only prospective cohort studies were included. From each study, data on the association between cognitive impairment and stroke estimated with hazard ratios or relative risks with 95% confidence interval (CI) were extracted. For each study, risk of stroke per SD lower performance in various cognitive tests was calculated.</jats:p> </jats:sec> <jats:sec> <jats:title>Results—</jats:title> <jats:p>Twelve studies were included, comprising 82 899 participants of whom 3043 had an incident stroke. The pooled relative risk per SD lower global cognitive performance was 1.19 (95% CI, 1.12–1.27). Each SD lower score in executive function or attention was associated with 1.14-fold (95% CI, 1.06–1.24) higher risk of stroke. Lower scores in memory were associated with 1.07-fold (95% CI, 1.02–1.12) higher risk of stroke, and lower scores in language were associated with 1.08-fold (95% CI, 1.02–1.16) higher risk of stroke.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions—</jats:title> <jats:p>Cognitive impairment is associated with higher risk of stroke. The associations were not significantly different for executive function, memory, and language.</jats:p> </jats:sec>
Journal
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- Stroke
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Stroke 45 (5), 1342-1348, 2014-05
Ovid Technologies (Wolters Kluwer Health)
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Details 詳細情報について
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- CRID
- 1361137043492739584
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- ISSN
- 15244628
- 00392499
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- Data Source
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- Crossref