Measles virus P gene codes for two proteins

書誌事項

公開日
1985-03
権利情報
  • https://journals.asm.org/non-commercial-tdm-license
DOI
  • 10.1128/jvi.53.3.908-919.1985
公開者
American Society for Microbiology

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説明

<jats:p>The entirety of the phosphoprotein gene of measles virus has been sequenced. The gene is composed of 1,657 nucleotides and specifies a 507-amino-acid protein (P). A second overlapping reading frame was predicted from the sequence and specifies a 186-amino-acid protein (C). Through the use of antisynthetic peptide antibodies, we show that both proteins are expressed in virally infected cells. Both proteins are expressed from a functionally bicistronic mRNA through independent initiation of ribosomes at the respective AUG codons. Using immunofluorescent microscopy, we localized the C protein in the nucleus and in cytoplasmic inclusions within the infected cells.</jats:p>

収録刊行物

  • Journal of Virology

    Journal of Virology 53 (3), 908-919, 1985-03

    American Society for Microbiology

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