Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea

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  • Cai-Huan Huang
    School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China
  • Jia-Hui Pan
    School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China
  • Bin Chen
    School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China
  • Miao Yu
    School of Science and Engineering, Jinan University, Guangzhou 510632, China
  • Hong-Bo Huang
    School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China
  • Xun Zhu
    Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism (Sun Yat-sen University), Bureau of Education of Guangdong, Guangzhou 510080, China
  • Yong-Jun Lu
    School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China
  • Zhi-Gang She
    School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China
  • Yong-Cheng Lin
    School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China

Description

<jats:p>Three new bianthraquinone derivatives, alterporriol K (1), L (2) and M (3), along with six known compounds were obtained from extracts of the endophytic fungus Alternaria sp. ZJ9-6B, isolated from the mangrove Aegiceras corniculatum collected in the South China Sea. Their structures were elucidated by one- and two-dimensional NMR spectroscopy, MS data analysis and circular dichroism measurements. Compounds 1, 2 and 3 were first isolated alterporriols with a C-2–C-2′ linkage. The crystallographic data of tetrahydroaltersolanol B (7) was reported for the first time. In the primary bioassays, alterporriol K and L exhibited moderate cytotoxic activity towards MDA-MB-435 and MCF-7 cells with IC50 values ranging from 13.1 to 29.1 µM.</jats:p>

Journal

  • Marine Drugs

    Marine Drugs 9 (5), 832-843, 2011-05-12

    MDPI AG

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