Coordinated Regulation of Iron-Controlling Genes, H-Ferritin and <i>IRP2</i> , by c-MYC
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- Kou-Juey Wu
- K.-J. Wu and R. Dalla-Favera, Division of Oncology, Department of Pathology, Columbia University, New York, NY 10032, USA. A. Polack, Institute for Clinical Molecular Biology and Tumor Genetics, GSF, National Research Institute for Environment and Health, Marchioninistrasse 25, D-81377 Munchen, Germany.
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- Axel Polack
- K.-J. Wu and R. Dalla-Favera, Division of Oncology, Department of Pathology, Columbia University, New York, NY 10032, USA. A. Polack, Institute for Clinical Molecular Biology and Tumor Genetics, GSF, National Research Institute for Environment and Health, Marchioninistrasse 25, D-81377 Munchen, Germany.
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- Riccardo Dalla-Favera
- K.-J. Wu and R. Dalla-Favera, Division of Oncology, Department of Pathology, Columbia University, New York, NY 10032, USA. A. Polack, Institute for Clinical Molecular Biology and Tumor Genetics, GSF, National Research Institute for Environment and Health, Marchioninistrasse 25, D-81377 Munchen, Germany.
書誌事項
- 公開日
- 1999-01-29
- DOI
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- 10.1126/science.283.5402.676
- 公開者
- American Association for the Advancement of Science (AAAS)
この論文をさがす
説明
<jats:p> The protein encoded by the c- <jats:italic>MYC</jats:italic> proto-oncogene is a transcription factor that can both activate and repress the expression of target genes, but few of its transcriptional targets have been identified. Here, c-MYC is shown to repress the expression of the heavy subunit of the protein ferritin (H-ferritin), which sequesters intracellular iron, and to stimulate the expression of the iron regulatory protein–2 (IRP2), which increases the intracellular iron pool. Down-regulation of the expression of H-ferritin gene was required for cell transformation by c-MYC. These results indicate that c-MYC coordinately regulates genes controlling intracellular iron concentrations and that this function is essential for the control of cell proliferation and transformation by c-MYC. </jats:p>
収録刊行物
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- Science
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Science 283 (5402), 676-679, 1999-01-29
American Association for the Advancement of Science (AAAS)