A G Protein Couples Serotonin and GABA <sub>B</sub> Receptors to the Same Channels in Hippocampus

DOI Web Site 被引用文献9件
  • R. Andrade
    Departments of Pharmacology and Physiology, University of California, San Francisco, CA 94143.
  • R. C. Malenka
    Departments of Pharmacology and Physiology, University of California, San Francisco, CA 94143.
  • R. A. Nicoll
    Departments of Pharmacology and Physiology, University of California, San Francisco, CA 94143.

書誌事項

公開日
1986-12-05
DOI
  • 10.1126/science.2430334
公開者
American Association for the Advancement of Science (AAAS)

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説明

<jats:p> Both serotonin and the selective γ-aminobutyric acid <jats:sub>B</jats:sub> (GABA <jats:sub>B</jats:sub> ) agonist, baclofen, increase potassium (K <jats:sup>+</jats:sup> ) conductance in hippocampal pyramidal cells. Although these agonists act on separate receptors, the potassium currents evoked by the agonists are not additive, indicating that the two receptors share the same potassium channels. Experiments with hydrolysis-resistant guanosine triphosphate (GTP) and guanosine diphosphate analogs and pertussis toxin indicate that the opening of the potassium channels by serotonin and GABA <jats:sub>B</jats:sub> receptors involves a pertussis toxin-sensitive GTP-binding (G) protein, which may directly couple the two receptors to the potassium channel. </jats:p>

収録刊行物

  • Science

    Science 234 (4781), 1261-1265, 1986-12-05

    American Association for the Advancement of Science (AAAS)

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