In vivo depletion of CD8+ T lymphocytes abrogates protective immunity to African swine fever virus

DOI Web Site 被引用文献1件
  • C. A. L. Oura
    Institute for Animal Health, Ash Road, Pirbright, Woking, Surrey GU24 0NF, UK
  • M. S. Denyer
    Institute for Animal Health, Ash Road, Pirbright, Woking, Surrey GU24 0NF, UK
  • H. Takamatsu
    Institute for Animal Health, Ash Road, Pirbright, Woking, Surrey GU24 0NF, UK
  • R. M. E. Parkhouse
    Institute for Animal Health, Ash Road, Pirbright, Woking, Surrey GU24 0NF, UK

書誌事項

公開日
2005-09-01
DOI
  • 10.1099/vir.0.81038-0
公開者
Microbiology Society

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説明

<jats:p>To understand the mechanisms involved in protective immunity to African swine fever virus (ASFV) infection, the observation that infection with the avirulent Portuguese ASFV isolate OUR/T88/3 protects outbred pigs from challenge with the virulent Portuguese ASFV isolate OUR/T88/1 was exploited. It was demonstrated that pigs exposed to OUR/T88/3 and then depleted of CD8<jats:sup>+</jats:sup>lymphocytes were no longer fully protected from OUR/T88/1 challenge. This indicated that CD8<jats:sup>+</jats:sup>lymphocytes play an important role in the protective immune response to ASFV infection and that anti-ASFV antibody alone, from OUR/T88/3 infection, was not sufficient to protect pigs from OUR/T88/1 challenge. Inbred pigs of the cc haplotype infected with OUR/T88/3 were not always protected from OUR/T88/1 challenge and developed both viraemia and fever. Such viraemia was always correlated with increased numbers of circulating CD8<jats:italic>β</jats:italic><jats:sup>+</jats:sup>lymphocytes, indicating a specific role for CD8<jats:italic>β</jats:italic><jats:sup>+</jats:sup>lymphocytes in combating viraemia. These experiments indicate an important role for CD8<jats:sup>+</jats:sup>lymphocytes, particularly CD8<jats:italic>β</jats:italic><jats:sup>+</jats:sup>lymphocytes, in ASF protective immunity.</jats:p>

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