Midlife vascular risk factors and midlife cognitive status in relation to prevalence of mild cognitive impairment and dementia in later life: The Atherosclerosis Risk in Communities Study

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  • David S. Knopman
    Department of Neurology Mayo Clinic Rochester MN USA
  • Rebecca F. Gottesman
    Department of Neurology Johns Hopkins University School of Medicine Baltimore MD USA
  • A. Richey Sharrett
    Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore MD USA
  • Amanda L. Tapia
    Department of Biostatistics University of North Carolina at Chapel Hill Chapel Hill NC USA
  • Sonia DavisThomas
    Department of Medicine University of Mississippi Medical Center Jackson MS USA
  • B. Gwen Windham
    Division of Public Health Sciences School of Medicine Wake Forest University Winston‐Salem NC USA
  • Laura Coker
    Department of Epidemiology Rollins School of Public Health Emory University Atlanta GA USA
  • Andrea L.C. Schneider
    Department of Neurology Johns Hopkins University School of Medicine Baltimore MD USA
  • Alvaro Alonso
    Department of Epidemiology Rollins School of Public Health Emory University Atlanta GA USA
  • Josef Coresh
    Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore MD USA
  • Marilyn S. Albert
    Department of Neurology Johns Hopkins University School of Medicine Baltimore MD USA
  • Thomas H. Mosley
    Department of Medicine University of Mississippi Medical Center Jackson MS USA

説明

<jats:title>Abstract</jats:title><jats:sec><jats:title>Introduction</jats:title><jats:p>The interplay between midlife vascular risk factors and midlife cognitive function with later life mild cognitive impairment (MCI) and dementia (DEM) is not well understood.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>In the Atherosclerosis Risk in Communities Study, cardiovascular risk factors and cognition were assessed in midlife, ages 45–64 years. In 2011–2013, 20–25 years later, all consenting Atherosclerosis Risk in Communities participants underwent a cognitive and neurological evaluation and were given adjudicated diagnoses of cognitively normal, MCI, or DEM.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>In 5995 participants with complete covariate data, midlife diabetes, hypertension, obesity, and hypercholesterolemia were associated with late‐life MCI and DEM. Low midlife cognition function was also associated with greater likelihood of late‐life MCI or DEM. Both midlife vascular risk factors and midlife cognitive function remained associated with later life MCI or DEM when both were in the model.</jats:p></jats:sec><jats:sec><jats:title>Discussion</jats:title><jats:p>Later life MCI and DEM were independently associated with midlife vascular risk factors and midlife cognition.</jats:p></jats:sec>

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