Renin gene polymorphism: its relationship to hypertension, renin levels and vascular responses

DOI Web Site 被引用文献2件
  • Bei Sun
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
  • Jonathan S Williams
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
  • Luminita Pojoga
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
  • Bindu Chamarthi
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
  • Jessica Lasky-Su
    Channing Laboratory, Brigham and Women’s Hospital, Boston, MA, USA
  • Benjamin A Raby
    Channing Laboratory, Brigham and Women’s Hospital, Boston, MA, USA
  • Paul N Hopkins
    Cardiovascular Genetics Research, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA
  • Xavier Jeunemaitre
    Centre d’Investigation Clinique, Hopital Broussais and INSERM U36 College de France, Paris, France
  • Nancy J Brown
    Vanderbilt University Medical Center, Nashville, TN, USA
  • Claudio Ferri
    Department of Internal Medicine and Public Health, University of L’Aquila, L’Aquila, Italy
  • Gordon H Williams
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

説明

<jats:p> The renin gene has been previously reported to be associated with essential hypertension in a variety of ethnic groups. However, no studies have systematically evaluated the relationship between single nucleotide polymorphisms (SNPs) representing coverage of the entire renin gene and hypertension risk. To evaluate the association between renin gene variation and hypertension we investigated data on HyperPATH cohort with 570 hypertensive and 222 normotensive Caucasian subjects. Six tagging SNPs and resultant haplotypes were tested for associations with hypertension risk, followed by mean arterial pressure (MAP), plasma renin activity (PRA) and the change in MAP in response to angiotensin II (AngII) infusion (AngII ΔMAP). The A allele of SNP rs6693954 and the haplotype containing rs6696954A were significantly associated with higher risk for hypertension (OR = 1.98, p = 0.0001; OR = 1.63 p = 0.0005, respectively). The same haplotype block was also associated with altered PRA levels and blunted AngII ΔMAP (global p-value = 0.02, 0.047, respectively). Our results confirm that polymorphisms in the renin gene are associated with increased risk for hypertension in an independent cohort, and that the underlying mechanism may reside in the interaction of renin activity and vascular responsiveness to angiotensin II. </jats:p>

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