Nuclear spin singlet states as a contrast mechanism for NMR spectroscopy

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  • Stephen J. DeVience
    Department of Chemistry and Chemical Biology Harvard University 12 Oxford St Cambridge MA 02138 USA
  • Ronald L. Walsworth
    Harvard‐Smithsonian Center for Astrophysics 60 Garden St Cambridge MA 02138 USA
  • Matthew S. Rosen
    Department of Physics Harvard University 17 Oxford St Cambridge MA 02138 USA

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<jats:p>Nuclear magnetic resonance (NMR) spectra of complex chemical mixtures often contain unresolved or hidden spectral components, especially when strong background signals overlap weaker peaks. In this article we demonstrate a quantum filter utilizing nuclear spin singlet states, which allows undesired NMR spectral background to be removed and target spectral peaks to be uncovered. The quantum filter is implemented by creating a nuclear spin singlet state with spin quantum numbers <jats:italic>j</jats:italic> = 0, <jats:italic>m</jats:italic><jats:sub><jats:italic>z</jats:italic></jats:sub> = 0 in a target molecule, applying a continuous RF field to both preserve the singlet state and saturate the magnetization of undesired molecules and then mapping the target molecule singlet state back into an NMR observable state so that its spectrum can be read out unambiguously. The preparation of the target singlet state can be carefully controlled with pulse sequence parameters, so that spectral contrast can be achieved between molecules with very similar structures. We name this NMR contrast mechanism ‘Suppression of Undesired Chemicals using Contrast‐Enhancing Singlet States’ (SUCCESS) and we demonstrate it <jats:italic>in vitro</jats:italic> for three target molecules relevant to neuroscience: aspartate, threonine and glutamine. Copyright © 2013 John Wiley & Sons, Ltd.</jats:p>

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