Salivary fetuin‐A, S100A12, and high‐sensitivity C‐reactive protein levels in periodontal diseases

<jats:title>Abstract</jats:title><jats:sec><jats:title>Aim</jats:title><jats:p>Hs‐CRP, fetuin‐A, and S100A12 are acute‐phase proteins associated with many systemic diseases and conditions. The aim of this study was to determine the clinical parameters and salivary Hs‐CRP, fetuin‐A, and S100A12 levels before and after nonsurgical periodontal treatments in the patients with periodontal diseases.</jats:p></jats:sec><jats:sec><jats:title>Materials and Methods</jats:title><jats:p>A total of 54 subjects were divided into three groups of 18 patients each: periodontally healthy, gingivitis, and chronic periodontitis. Clinical periodontal parameters; salivary Hs‐CRP, fetuin‐A, and S100A12 levels; and salivary flow rates were evaluated at baseline and a month after the treatments.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Fetuin‐A and S100A12 were significantly lower and Hs‐CRP levels were significantly higher in the chronic periodontitis and gingivitis groups than in the control group at baseline (<jats:italic>p </jats:italic>< 0.01). For the gingivitis and chronic periodontitis groups, the posttreatment levels of salivary fetuin‐A and S100A12 were higher than the baseline levels of the same (<jats:italic>p </jats:italic>< 0.01). There was a negative correlation between Hs‐CRP and fetuin‐A and Hs‐CRP and S100A12 (<jats:italic>p </jats:italic>< 0.001) and a positive correlation between fetuin‐A and S100A12 (<jats:italic>p </jats:italic>< 0.05) at baseline.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Salivary fetuin‐A and S100A12 levels decreased with increasing severity of periodontal disease. These results suggest that salivary fetuin‐A may play an important role as a negative acute‐phase protein in periodontal diseases.</jats:p></jats:sec>