Improvement of solubility and dissolution rate of poorly water-soluble salicylic acid by a spray-drying technique

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  • Y Kawashima
    Gifu College of Pharmacy , Mitahora, Gifu 502,
  • M Saito
    Gifu College of Pharmacy , Mitahora, Gifu 502,
  • H Takenaka
    Gifu College of Pharmacy , Mitahora, Gifu 502,

Bibliographic Information

Published
1975-01-01
Rights Information
  • https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model
DOI
  • 10.1111/j.2042-7158.1975.tb09369.x
Publisher
Oxford University Press (OUP)

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<jats:title>Abstract</jats:title> <jats:p>Spray drying techniques have been applied to improve the solubility and dissolution rate of poorly water-soluble salicylic acid. Spray drying of the acid dispersed in acacia solutions resulted in as much as a 50% improvement in the solubility of the product. Solubility improvement was closely related not only to the concentration of acacia but also the amount of amorphous material in the spray-dried products. The heat of solution was inversely related to these parameters. The dissolution rate of spray-dried product was almost instantaneous being about 60 times faster than that of the original powder. A great improvement in the wettability of the spray-dried material seemed to be mainly responsible for the increase of dissolution rate.</jats:p>

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