Physiological roles of ATP‐sensitive K<sup>+</sup> channels in smooth muscle
書誌事項
- 公開日
- 2006-04-21
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1113/jphysiol.2006.105973
- 公開者
- Wiley
この論文をさがす
説明
<jats:p>Potassium channels that are inhibited by intracellular ATP (ATP<jats:sub>i</jats:sub>) were first identified in ventricular myocytes, and are referred to as ATP‐sensitive K<jats:sup>+</jats:sup> channels (i.e. K<jats:sub>ATP</jats:sub> channels). Subsequently, K<jats:sup>+</jats:sup> channels with similar characteristics have been demonstrated in many other tissues (pancreatic β‐cells, skeletal muscle, central neurones, smooth muscle). Approximately one decade ago, K<jats:sub>ATP</jats:sub> channels were cloned and were found to be composed of at least two subunits: an inwardly rectifying K<jats:sup>+</jats:sup> channel six family (Kir6.x) that forms the ion conducting pore and a modulatory sulphonylurea receptor (SUR) that accounts for several pharmacological properties. Various types of native K<jats:sub>ATP</jats:sub> channels have been identified in a number of visceral and vascular smooth muscles in single‐channel recordings. However, little attention has been paid to the molecular properties of the subunits in K<jats:sub>ATP</jats:sub> channels and it is important to determine the relative expression of K<jats:sub>ATP</jats:sub> channel components which give rise to native K<jats:sub>ATP</jats:sub> channels in smooth muscle. The aim of this review is to briefly discuss the current knowledge available for K<jats:sub>ATP</jats:sub> channels with the main interest in the molecular basis of native K<jats:sub>ATP</jats:sub> channels, and to discuss their possible linkage with physiological functions in smooth muscle.</jats:p>
収録刊行物
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- The Journal of Physiology
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The Journal of Physiology 572 (3), 617-624, 2006-04-21
Wiley