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- Stefan Feske
- Department of Pathology,
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- Heike Wulff
- Department of Pharmacology, School of Medicine, University of California, Davis, California 95616
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- Edward Y. Skolnik
- Division of Nephrology,
説明
<jats:p>Ion channels and transporters mediate the transport of charged ions across hydrophobic lipid membranes. In immune cells, divalent cations such as calcium, magnesium, and zinc have important roles as second messengers to regulate intracellular signaling pathways. By contrast, monovalent cations such as sodium and potassium mainly regulate the membrane potential, which indirectly controls the influx of calcium and immune cell signaling. Studies investigating human patients with mutations in ion channels and transporters, analysis of gene-targeted mice, or pharmacological experiments with ion channel inhibitors have revealed important roles of ionic signals in lymphocyte development and in innate and adaptive immune responses. We here review the mechanisms underlying the function of ion channels and transporters in lymphocytes and innate immune cells and discuss their roles in lymphocyte development, adaptive and innate immune responses, and autoimmunity, as well as recent efforts to develop pharmacological inhibitors of ion channels for immunomodulatory therapy.</jats:p>
収録刊行物
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- Annual Review of Immunology
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Annual Review of Immunology 33 (1), 291-353, 2015-03-21
Annual Reviews