Increase in Pulmonary Ventilation–Perfusion Inequality with Age in Healthy Individuals

DOI PDF 被引用文献1件
  • JAUME CARDÚS
    Departament de Medicina, Hospital Cinic, Universitat de Barcelona, Barcelona, Spain; and Department of Medicine, University of California, San Diego, La Jolla, California
  • FELIP BURGOS
    Departament de Medicina, Hospital Cinic, Universitat de Barcelona, Barcelona, Spain; and Department of Medicine, University of California, San Diego, La Jolla, California
  • ORLANDO DIAZ
    Departament de Medicina, Hospital Cinic, Universitat de Barcelona, Barcelona, Spain; and Department of Medicine, University of California, San Diego, La Jolla, California
  • JOSEP ROCA
    Departament de Medicina, Hospital Cinic, Universitat de Barcelona, Barcelona, Spain; and Department of Medicine, University of California, San Diego, La Jolla, California
  • JOAN ALBERT BARBERÁ
    Departament de Medicina, Hospital Cinic, Universitat de Barcelona, Barcelona, Spain; and Department of Medicine, University of California, San Diego, La Jolla, California
  • RAMÓN M. MARRADES
    Departament de Medicina, Hospital Cinic, Universitat de Barcelona, Barcelona, Spain; and Department of Medicine, University of California, San Diego, La Jolla, California
  • ROBERT RODRIGUEZ-ROISIN
    Departament de Medicina, Hospital Cinic, Universitat de Barcelona, Barcelona, Spain; and Department of Medicine, University of California, San Diego, La Jolla, California
  • PETER D. WAGNER
    Departament de Medicina, Hospital Cinic, Universitat de Barcelona, Barcelona, Spain; and Department of Medicine, University of California, San Diego, La Jolla, California

書誌事項

公開日
1997-08-01
権利情報
  • https://academic.oup.com/pages/standard-publication-reuse-rights
DOI
  • 10.1164/ajrccm.156.2.9606016
公開者
Oxford University Press (OUP)

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<jats:title>Abstract</jats:title> <jats:p>Arterial oxygen tension (PaO2) is known to decrease with age, and this is accompanied by a number of changes in mechanical properties of the lungs, including loss of elastic recoil and increase in closing volume. The changes in respiratory mechanics with age could induce greater ventilation/perfusion (V̇a/Q̇) mismatch and thus explain the decrease in Pa O2. In 64 normal subjects aged 18 to 71 yr (lifetime nonsmokers with normal spirometry), we measured V̇a/Q̇ inequality and arterial respiratory blood gases (Pa O2 and PaCO2) at rest in the seated position. V̇a/Q̇ mismatch, represented by the second moments of the blood flow and ventilation distributions (log SDQ and log SDV) increased with age, but only slightly (mean log SDQ was 0.36 at age 20 yr and 0.47 at age 70 yr). Pa O2 fell by a correspondingly small amount of 6 mm Hg. Previously established upper 95% confidence limits for log SDQ (0.60) and log SDV (0.65) in subjects at age 20 yr were confirmed. At age 70 yr, the upper limits of reference for log SDQ are 0.70 and for log SDV 0.75. The study shows that an increased alveolar– arterial O2 gradient with age is due to V̇a/Q̇ inequality rather than to shunting.</jats:p>

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