Heterogeneous Organic Base-Catalyzed Reactions Enhanced by Acid Supports

  • Ken Motokura
    Department of Chemistry, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
  • Mizuki Tada
    Department of Chemistry, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
  • Yasuhiro Iwasawa
    Department of Chemistry, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

書誌事項

公開日
2007-07-13
DOI
  • 10.1021/ja0704333
公開者
American Chemical Society (ACS)

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説明

Amorphous silica-alumina-supported amines (SA-NR2) were found to be excellent heterogeneous catalysts for a variety of carbon−carbon bond-forming reactions, such as cyano-O-ethoxycarbonylation, Michael reaction, and nitro-aldol reaction. These reactions were hard to proceed either with amines alone or on the SA alone. Solid-state 13C MAS NMR analysis revealed the acid−base interaction of the H+ site and amine group on the SA-NR2 surface, which makes an acid−base dual activation mechanism possible for carbon−carbon bond-forming reactions.

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