Symmetry‐Guided Design and Fluorous Synthesis of a Stable and Rapidly Excreted Imaging Tracer for
                    <sup>19</sup>
                    F MRI

Zhong‐Xing Jiang, Xin Liu, Eun‐Kee Jeong, Yihua Bruce Yu

doi:10.1002/anie.200901005

Symmetry‐Guided Design and Fluorous Synthesis of a Stable and Rapidly Excreted Imaging Tracer for <sup>19</sup> F MRI

DOI Web Site Web Site 被引用文献1件

書誌事項

公開日: 2009-06-09

権利情報

http://onlinelibrary.wiley.com/termsAndConditions#vor

DOI

10.1002/anie.200901005

公開者: Wiley

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<jats:title>Abstract</jats:title> <jats:p> <jats:bold>Getting FIT</jats:bold> : A bispherical <jats:sup>19</jats:sup> F imaging tracer, <jats:sup>19</jats:sup> FIT, was designed and synthesized. <jats:sup>19</jats:sup> FIT is advantageous over perfluorocarbon‐based <jats:sup>19</jats:sup> F imaging agents, as it is not retained in the organs and does not require complex formulation procedures. Imaging agents such as <jats:sup>19</jats:sup> FIT can lead to <jats:sup>19</jats:sup> F magnetic resonance imaging (MRI) playing an important role in drug therapy, analogous to the role played by <jats:sup>1</jats:sup> H MRI in disease diagnosis. <jats:boxed-text content-type="graphic" position="anchor"> <jats:graphic xmlns:xlink="http://www.w3.org/1999/xlink" mimetype="image/gif" position="anchor" specific-use="enlarged-web-image" xlink:href="graphic/mcontent.gif"> <jats:alt-text>magnified image</jats:alt-text> </jats:graphic> </jats:boxed-text> </jats:p>