Dynamic BMP signaling polarized by Toll patterns the dorsoventral axis in a hemimetabolous insect

Lena Sachs, Yen-Ta Chen, Axel Drechsler, Jeremy A Lynch, Kristen A Panfilio, Michael Lässig, Johannes Berg, Siegfried Roth

doi:10.7554/elife.05502

Dynamic BMP signaling polarized by Toll patterns the dorsoventral axis in a hemimetabolous insect

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Lena Sachs

Institute for Developmental Biology, University of Cologne, Köln, Germany
Yen-Ta Chen

Institute for Developmental Biology, University of Cologne, Köln, Germany
Axel Drechsler

Institute for Developmental Biology, University of Cologne, Köln, Germany
Jeremy A Lynch

Institute for Developmental Biology, University of Cologne, Köln, Germany
Kristen A Panfilio

Institute for Developmental Biology, University of Cologne, Köln, Germany
Michael Lässig

Institute for Theoretical Physics, University of Cologne, Cologne, Germany
Johannes Berg

Institute for Theoretical Physics, University of Cologne, Cologne, Germany
Siegfried Roth

Institute for Developmental Biology, University of Cologne, Köln, Germany

書誌事項

公開日: 2015-05-12

権利情報

http://creativecommons.org/licenses/by/4.0/
http://creativecommons.org/licenses/by/4.0/
http://creativecommons.org/licenses/by/4.0/

DOI

10.7554/elife.05502

公開者: eLife Sciences Publications, Ltd

説明

<jats:p>Toll-dependent patterning of the dorsoventral axis in Drosophila represents one of the best understood gene regulatory networks. However, its evolutionary origin has remained elusive. Outside the insects Toll is not known for a patterning function, but rather for a role in pathogen defense. Here, we show that in the milkweed bug Oncopeltus fasciatus, whose lineage split from Drosophila's more than 350 million years ago, Toll is only required to polarize a dynamic BMP signaling network. A theoretical model reveals that this network has self-regulatory properties and that shallow Toll signaling gradients are sufficient to initiate axis formation. Such gradients can account for the experimentally observed twinning of insect embryos upon egg fragmentation and might have evolved from a state of uniform Toll activity associated with protecting insect eggs against pathogens.</jats:p>