Tau in Alzheimer's Disease: Mechanisms and Therapeutic Strategies

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  • Yu Gao
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China
  • Lin Tan
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China
  • Jin-Tai Yu
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China
  • Lan Tan
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China

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<jats:sec> <jats:title /> <jats:p>Objective: Alzheimer's disease (AD), the most important progressive neurodegenerative disorder, is characterized by cognitive and behavioral disabilities. Nowadays, tau, as a microtubuleassociated protein and a principle neuropathological hallmark of AD, provides us a neoteric perspective to explore further aetiopathogenesis and therapeutic strategy. The hyperphosphorylation and abnormal aggregation of tau, combined with its decreased clearance, form neurofibrillary tangles (NFTs) and exert neurotoxicity in AD. </jats:p></jats:sec> <jats:sec> <jats:title>Methods:</jats:title> <jats:p> Recent investigations aim to prevent the deposition of NFT and accelerate the clearance of NFT. Intriguingly, immunization strategies targeting tau effectively ameliorates the tau-associated pathology in AD. In addition, modified therapies targeting tau should be regarded as a potential way to treat AD. These progresses open new avenues for AD. </jats:p></jats:sec> <jats:sec> <jats:title>Conclusion:</jats:title> <jats:p> Here, we review the recent literature of potential mechanisms of the tau in AD and discuss the modified therapeutic strategies for AD.</jats:p> </jats:sec>

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