Differential IL-17 Production and Mannan Recognition Contribute to Fungal Pathogenicity and Commensalism
-
- Lisa Rizzetto
- *Department of Preclinic and Clinic Pharmacology and
-
- Mirela Kuka
- †Novartis Vaccines, Siena, Italy;
-
- Carlotta De Filippo
- *Department of Preclinic and Clinic Pharmacology and
-
- Alessandra Cambi
- ‡Department of Tumor Immunology, Nijmegen Center for Molecular Life Science, Radboud University Nijmegen Medical Centre;
-
- Mihai G. Netea
- §Department of Medicine and Nijmegen Institute for Infection, Inflammation and Immunity, Radboud University, Nijmegen, The Netherlands; and
-
- Luca Beltrame
- *Department of Preclinic and Clinic Pharmacology and
-
- Giorgio Napolitani
- ¶Institute of Research in Biomedicine, Bellinzona, Switzerland
-
- Maria Gabriella Torcia
- ‖Department of Clinic Physiopathology, University of Firenze, Firenze;
-
- Ugo D’Oro
- †Novartis Vaccines, Siena, Italy;
-
- Duccio Cavalieri
- *Department of Preclinic and Clinic Pharmacology and
説明
<jats:title>Abstract</jats:title> <jats:p>In this study, we present evidence of differential Th17 responses in human monocyte-derived dendritic cells exposed to the pathogenic Candida albicans or the nonpathogenic Saccharomyces cerevisiae. We use different forms of the microorganisms, cells, hyphae, and spores, as a toolbox to dissect the role of surface mannan in the fungal immune response. In contrast to the S. cerevisiae yeast cell-induced Th1 response, dendritic cells stimulated with spores or C. albicans hyphae induce cellular responses shifted toward Th17 differentiation. The differential recognition of specific mannan structures is the master regulator of the discrimination between harmful and harmless fungi. The switch between spores and yeast is crucial for the commensalism of S. cerevisiae and depends on the use of a different receptor repertoire. Understanding the role of cell wall recognition during infection might lead to understanding the boundaries between safety and pathogenicity.</jats:p>
収録刊行物
-
- The Journal of Immunology
-
The Journal of Immunology 184 (8), 4258-4268, 2010-04-15
The American Association of Immunologists