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- Evan Heller
- Howard Hughes Medical Institute, Robin Neustein Chemers Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065
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- Elaine Fuchs
- Howard Hughes Medical Institute, Robin Neustein Chemers Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065
説明
<jats:p>In development, cells organize into biological tissues through cell growth, migration, and differentiation. Globally, this process is dictated by a genetically encoded program in which secreted morphogens and cell–cell interactions prompt the adoption of unique cell fates. Yet, at its lowest level, development is achieved through the modification of cell–cell adhesion and actomyosin-based contractility, which set the level of tension within cells and dictate how they pack together into tissues. The regulation of tension within individual cells and across large groups of cells is a major driving force of tissue organization and the basis of all cell shape change and cell movement in development.</jats:p>
収録刊行物
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- Journal of Cell Biology
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Journal of Cell Biology 211 (2), 219-231, 2015-10-26
Rockefeller University Press