Worsening of Anemia by Angiotensin Converting Enzyme Inhibitors and Its Prevention by Antiestrogenic Steroid in Chronic Hemodialysis Patients
書誌事項
- 公開日
- 1989
- DOI
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- 10.1097/00005344-198900133-00007
- 公開者
- Ovid Technologies (Wolters Kluwer Health)
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説明
The effects of angiotensin converting enzyme (ACE) inhibitors and their combined use with an antiestrogenic steroid on erythropoiesis were investigated in patients on chronic hemodialysis (CHD). Hematocrit was decreased by 10% or more in 6 of 12 patients who received either captopril or enalapril for 2-6 months. Erythropoietin (Epo) and angiotensin II (AII) were significantly reduced in these patients. When treatment with mepitiostane was combined with ACE inhibitor, anemia was significantly improved but without evidence of changes in circulating Epo concentrations or indices of renin-angiotensin activity. The reduction of AII and Epo formation by ACE inhibitors seems to play an important role in the worsening of anemia in patients on CHD; addition of an antiestrogenic steroid should be considered.
収録刊行物
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- Journal of Cardiovascular Pharmacology
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Journal of Cardiovascular Pharmacology 13 S27-S30, 1989
Ovid Technologies (Wolters Kluwer Health)