Cardiac Gene Transfer of Short Hairpin RNA Directed Against Phospholamban Effectively Knocks Down Gene Expression but Causes Cellular Toxicity in Canines

  • Lawrence T. Bish
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104.
  • Meg M. Sleeper
    Section of Cardiology, Department of Clinical Studies, Veterinary Hospital of the University of Pennsylvania, Philadelphia, PA 19104.
  • Caryn Reynolds
    Section of Cardiology, Department of Clinical Studies, Veterinary Hospital of the University of Pennsylvania, Philadelphia, PA 19104.
  • Jeffrey Gazzara
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104.
  • Elanor Withnall
    Section of Cardiology, Department of Clinical Studies, Veterinary Hospital of the University of Pennsylvania, Philadelphia, PA 19104.
  • Gretchen E. Singletary
    Section of Cardiology, Department of Clinical Studies, Veterinary Hospital of the University of Pennsylvania, Philadelphia, PA 19104.
  • George Buchlis
    Division of Hematology and Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, and Howard Hughes Medical Institute, Philadelphia, PA 19104.
  • Daniel Hui
    Division of Hematology and Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, and Howard Hughes Medical Institute, Philadelphia, PA 19104.
  • Katherine A. High
    Division of Hematology and Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, and Howard Hughes Medical Institute, Philadelphia, PA 19104.
  • Guangping Gao
    Department of Molecular Genetics and Microbiology, Gene Therapy Center, University of Massachusetts School of Medicine, Worcester, MA 01605.
  • James M. Wilson
    Division of Medical Genetics, Gene Therapy Program, University of Pennsylvania School of Medicine, Translational Research Laboratory, Philadelphia, PA 19104.
  • H. Lee Sweeney
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104.

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