Polycomb-mediated chromatin loops revealed by a subkilobase-resolution chromatin interaction map

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  • Kyle P. Eagen
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305;
  • Erez Lieberman Aiden
    The Center for Genome Architecture, Baylor College of Medicine, Houston, TX 77030;
  • Roger D. Kornberg
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305;

Description

<jats:title>Significance</jats:title> <jats:p> Chromatin loops, detected by chemical cross-linking and DNA sequencing, are frequently bounded by the polycomb repressive complex 1 in <jats:italic>Drosophila</jats:italic> . The loops are associated with important developmental genes, often in a repressed state. These results are in contrast with previous studies on mammalian cells, in which chromatin loops are commonly bounded by CTCF protein, and with the generally accepted role of looping in gene activation. </jats:p>

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