Nonenzymatic Glycosylation Products on Collagen Covalently Trap Low-Density Lipoprotein
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- Michael Brownlee
- Laboratory of Medical Biochemistry, The Rockefeller University 1230 York Avenue, New York, New York 10021
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- Helen Vlassara
- Laboratory of Medical Biochemistry, The Rockefeller University 1230 York Avenue, New York, New York 10021
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- Anthony Cerami
- Laboratory of Medical Biochemistry, The Rockefeller University 1230 York Avenue, New York, New York 10021
書誌事項
- 公開日
- 1985-09-01
- DOI
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- 10.2337/diab.34.9.938
- 公開者
- American Diabetes Association
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説明
<jats:p>Advanced nonenzymatic glycosylation products capable of cross-linking proteins accumulate on collagen in vivo in proportion to time-averaged blood glucose concentration. In this report, we have evaluated the ability of advanced nonenzymatic glycosylation productsformed on collagen in vitro to covalently bind low-density lipoprotein (LDL) in a manner similar to that which occurs in human atherosclerotic lesions. At constant LDL concentration, covalent trapping increased linearly with the extent of advanced glycosylation product formation, from 1.42 ± 0.15 to 4.46 ± 0.36 μg LDL protein/mg collagen. At a constant level of collagen advancedglycosylation product, LDL binding increased as a function of increasing LDL concentration. At anLDL-cholesterol level of 103 mg/dl, covalent trapping of LDL by nonenzymatic glycosylation products on collagen averaged 3.2 times as much as control (P < 0.01).</jats:p> <jats:p>These data indicate that LDL is bound specifically by reactive products generated by nonenzymatic glycosylation of collagen, and suggest that excessive LDL trapping by hyperglycemia-induced advanced glycosylation endproducts may contribute to the accelerated development of atherosclerosis in patients with diabetes mellitus.</jats:p>
収録刊行物
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- Diabetes
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Diabetes 34 (9), 938-941, 1985-09-01
American Diabetes Association