Combination of silyl carbamate and amino acid fluoride for solid-phase peptide synthesis
説明
Abstract Diketopiperadine (DKP) formation is an often encountered side reaction in the synthesis of peptide having C-terminal proline ester. A novel strategy for the avoidance of this side reaction was developed, which utilizes Pfp ester of Tsoc-amino acid and Fmoc-amino acid fluoride as the second and the third amino acid, respectively. This strategy was applied to the synthesis of 37–53 fragment of the β-chain of human chorionic gonadotropin (hCG).
収録刊行物
-
- Tetrahedron Letters
-
Tetrahedron Letters 43 (8), 1515-1518, 2002-02
Elsevier BV
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1361137044922724608
-
- NII論文ID
- 30004225799
-
- ISSN
- 00404039
-
- データソース種別
-
- Crossref
- CiNii Articles
- OpenAIRE
