Mammalian MAPK Signal Transduction Pathways Activated by Stress and Inflammation: A 10-Year Update

DOI Web Site 被引用文献48件
  • John M. Kyriakis
    Molecular Cardiology Research Institute, Department of Medicine, Tufts Medical Center, and Diabetes Research Laboratory, Medical Services and Department of Molecular Biology, Massachusetts General Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts
  • Joseph Avruch
    Molecular Cardiology Research Institute, Department of Medicine, Tufts Medical Center, and Diabetes Research Laboratory, Medical Services and Department of Molecular Biology, Massachusetts General Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts

説明

<jats:p>The mammalian stress-activated families of mitogen-activated protein kinases (MAPKs) were first elucidated in 1994, and by 2001, substantial progress had been made in identifying the architecture of the pathways upstream of these kinases as well as in cataloguing candidate substrates. This information remains largely sound. Nevertheless, an informed understanding of the physiological and pathophysiological roles of these kinases remained to be accomplished. In the past decade, there has been an explosion of new work using RNAi in cells, as well as transgenic, knockout and conditional knockout technology in mice that has provided valuable insight into the functions of stress-activated MAPK pathways. These findings have important implications in our understanding of organ development, innate and acquired immunity, and diseases such as atherosclerosis, tumorigenesis, and type 2 diabetes. These new developments bring us within striking distance of the development and validation of novel treatment strategies. Herein we first summarize the molecular components of the mammalian stress-regulated MAPK pathways and their regulation as described thus far. We then review some of the in vivo functions of these pathways.</jats:p>

収録刊行物

被引用文献 (48)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ