Impact of Thrombophilia on Risk of Arterial Ischemic Stroke or Cerebral Sinovenous Thrombosis in Neonates and Children
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- Gili Kenet
- From the Israel National Haemophilia Centre, Sheba Medical Centre, Tel-Hashomer, Israel (G.K.); Department of Pediatric Hematology/Oncology, University Hospital of Münster, Münster, Germany (L.K.L., R.D.S., U.N.-G.); Division of Hematology, University Children’s Hospital, Zurich, Switzerland (M.A.); Department of Pediatrics, Hematology/Oncology/BMT, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, and Children’s Hospital, Denver/Aurora, Colo (T.B., N.A.G.,...
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- Lisa K. Lütkhoff
- From the Israel National Haemophilia Centre, Sheba Medical Centre, Tel-Hashomer, Israel (G.K.); Department of Pediatric Hematology/Oncology, University Hospital of Münster, Münster, Germany (L.K.L., R.D.S., U.N.-G.); Division of Hematology, University Children’s Hospital, Zurich, Switzerland (M.A.); Department of Pediatrics, Hematology/Oncology/BMT, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, and Children’s Hospital, Denver/Aurora, Colo (T.B., N.A.G.,...
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- Manuela Albisetti
- From the Israel National Haemophilia Centre, Sheba Medical Centre, Tel-Hashomer, Israel (G.K.); Department of Pediatric Hematology/Oncology, University Hospital of Münster, Münster, Germany (L.K.L., R.D.S., U.N.-G.); Division of Hematology, University Children’s Hospital, Zurich, Switzerland (M.A.); Department of Pediatrics, Hematology/Oncology/BMT, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, and Children’s Hospital, Denver/Aurora, Colo (T.B., N.A.G.,...
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- Timothy Bernard
- From the Israel National Haemophilia Centre, Sheba Medical Centre, Tel-Hashomer, Israel (G.K.); Department of Pediatric Hematology/Oncology, University Hospital of Münster, Münster, Germany (L.K.L., R.D.S., U.N.-G.); Division of Hematology, University Children’s Hospital, Zurich, Switzerland (M.A.); Department of Pediatrics, Hematology/Oncology/BMT, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, and Children’s Hospital, Denver/Aurora, Colo (T.B., N.A.G.,...
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- Mariana Bonduel
- From the Israel National Haemophilia Centre, Sheba Medical Centre, Tel-Hashomer, Israel (G.K.); Department of Pediatric Hematology/Oncology, University Hospital of Münster, Münster, Germany (L.K.L., R.D.S., U.N.-G.); Division of Hematology, University Children’s Hospital, Zurich, Switzerland (M.A.); Department of Pediatrics, Hematology/Oncology/BMT, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, and Children’s Hospital, Denver/Aurora, Colo (T.B., N.A.G.,...
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- Leonardo Brandao
- From the Israel National Haemophilia Centre, Sheba Medical Centre, Tel-Hashomer, Israel (G.K.); Department of Pediatric Hematology/Oncology, University Hospital of Münster, Münster, Germany (L.K.L., R.D.S., U.N.-G.); Division of Hematology, University Children’s Hospital, Zurich, Switzerland (M.A.); Department of Pediatrics, Hematology/Oncology/BMT, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, and Children’s Hospital, Denver/Aurora, Colo (T.B., N.A.G.,...
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- Stephane Chabrier
- From the Israel National Haemophilia Centre, Sheba Medical Centre, Tel-Hashomer, Israel (G.K.); Department of Pediatric Hematology/Oncology, University Hospital of Münster, Münster, Germany (L.K.L., R.D.S., U.N.-G.); Division of Hematology, University Children’s Hospital, Zurich, Switzerland (M.A.); Department of Pediatrics, Hematology/Oncology/BMT, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, and Children’s Hospital, Denver/Aurora, Colo (T.B., N.A.G.,...
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- Anthony Chan
- From the Israel National Haemophilia Centre, Sheba Medical Centre, Tel-Hashomer, Israel (G.K.); Department of Pediatric Hematology/Oncology, University Hospital of Münster, Münster, Germany (L.K.L., R.D.S., U.N.-G.); Division of Hematology, University Children’s Hospital, Zurich, Switzerland (M.A.); Department of Pediatrics, Hematology/Oncology/BMT, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, and Children’s Hospital, Denver/Aurora, Colo (T.B., N.A.G.,...
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- Gabrielle deVeber
- From the Israel National Haemophilia Centre, Sheba Medical Centre, Tel-Hashomer, Israel (G.K.); Department of Pediatric Hematology/Oncology, University Hospital of Münster, Münster, Germany (L.K.L., R.D.S., U.N.-G.); Division of Hematology, University Children’s Hospital, Zurich, Switzerland (M.A.); Department of Pediatrics, Hematology/Oncology/BMT, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, and Children’s Hospital, Denver/Aurora, Colo (T.B., N.A.G.,...
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- Barbara Fiedler
- From the Israel National Haemophilia Centre, Sheba Medical Centre, Tel-Hashomer, Israel (G.K.); Department of Pediatric Hematology/Oncology, University Hospital of Münster, Münster, Germany (L.K.L., R.D.S., U.N.-G.); Division of Hematology, University Children’s Hospital, Zurich, Switzerland (M.A.); Department of Pediatrics, Hematology/Oncology/BMT, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, and Children’s Hospital, Denver/Aurora, Colo (T.B., N.A.G.,...
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- Heather J. Fullerton
- From the Israel National Haemophilia Centre, Sheba Medical Centre, Tel-Hashomer, Israel (G.K.); Department of Pediatric Hematology/Oncology, University Hospital of Münster, Münster, Germany (L.K.L., R.D.S., U.N.-G.); Division of Hematology, University Children’s Hospital, Zurich, Switzerland (M.A.); Department of Pediatrics, Hematology/Oncology/BMT, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, and Children’s Hospital, Denver/Aurora, Colo (T.B., N.A.G.,...
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- Neil A. Goldenberg
- From the Israel National Haemophilia Centre, Sheba Medical Centre, Tel-Hashomer, Israel (G.K.); Department of Pediatric Hematology/Oncology, University Hospital of Münster, Münster, Germany (L.K.L., R.D.S., U.N.-G.); Division of Hematology, University Children’s Hospital, Zurich, Switzerland (M.A.); Department of Pediatrics, Hematology/Oncology/BMT, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, and Children’s Hospital, Denver/Aurora, Colo (T.B., N.A.G.,...
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- Eric Grabowski
- From the Israel National Haemophilia Centre, Sheba Medical Centre, Tel-Hashomer, Israel (G.K.); Department of Pediatric Hematology/Oncology, University Hospital of Münster, Münster, Germany (L.K.L., R.D.S., U.N.-G.); Division of Hematology, University Children’s Hospital, Zurich, Switzerland (M.A.); Department of Pediatrics, Hematology/Oncology/BMT, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, and Children’s Hospital, Denver/Aurora, Colo (T.B., N.A.G.,...
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- Gudrun Günther
- From the Israel National Haemophilia Centre, Sheba Medical Centre, Tel-Hashomer, Israel (G.K.); Department of Pediatric Hematology/Oncology, University Hospital of Münster, Münster, Germany (L.K.L., R.D.S., U.N.-G.); Division of Hematology, University Children’s Hospital, Zurich, Switzerland (M.A.); Department of Pediatrics, Hematology/Oncology/BMT, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, and Children’s Hospital, Denver/Aurora, Colo (T.B., N.A.G.,...
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- Christine Heller
- From the Israel National Haemophilia Centre, Sheba Medical Centre, Tel-Hashomer, Israel (G.K.); Department of Pediatric Hematology/Oncology, University Hospital of Münster, Münster, Germany (L.K.L., R.D.S., U.N.-G.); Division of Hematology, University Children’s Hospital, Zurich, Switzerland (M.A.); Department of Pediatrics, Hematology/Oncology/BMT, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, and Children’s Hospital, Denver/Aurora, Colo (T.B., N.A.G.,...
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- Susanne Holzhauer
- From the Israel National Haemophilia Centre, Sheba Medical Centre, Tel-Hashomer, Israel (G.K.); Department of Pediatric Hematology/Oncology, University Hospital of Münster, Münster, Germany (L.K.L., R.D.S., U.N.-G.); Division of Hematology, University Children’s Hospital, Zurich, Switzerland (M.A.); Department of Pediatrics, Hematology/Oncology/BMT, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, and Children’s Hospital, Denver/Aurora, Colo (T.B., N.A.G.,...
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- Alfonso Iorio
- From the Israel National Haemophilia Centre, Sheba Medical Centre, Tel-Hashomer, Israel (G.K.); Department of Pediatric Hematology/Oncology, University Hospital of Münster, Münster, Germany (L.K.L., R.D.S., U.N.-G.); Division of Hematology, University Children’s Hospital, Zurich, Switzerland (M.A.); Department of Pediatrics, Hematology/Oncology/BMT, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, and Children’s Hospital, Denver/Aurora, Colo (T.B., N.A.G.,...
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- Janna Journeycake
- From the Israel National Haemophilia Centre, Sheba Medical Centre, Tel-Hashomer, Israel (G.K.); Department of Pediatric Hematology/Oncology, University Hospital of Münster, Münster, Germany (L.K.L., R.D.S., U.N.-G.); Division of Hematology, University Children’s Hospital, Zurich, Switzerland (M.A.); Department of Pediatrics, Hematology/Oncology/BMT, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, and Children’s Hospital, Denver/Aurora, Colo (T.B., N.A.G.,...
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- Ralf Junker
- From the Israel National Haemophilia Centre, Sheba Medical Centre, Tel-Hashomer, Israel (G.K.); Department of Pediatric Hematology/Oncology, University Hospital of Münster, Münster, Germany (L.K.L., R.D.S., U.N.-G.); Division of Hematology, University Children’s Hospital, Zurich, Switzerland (M.A.); Department of Pediatrics, Hematology/Oncology/BMT, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, and Children’s Hospital, Denver/Aurora, Colo (T.B., N.A.G.,...
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- Fenella J. Kirkham
- From the Israel National Haemophilia Centre, Sheba Medical Centre, Tel-Hashomer, Israel (G.K.); Department of Pediatric Hematology/Oncology, University Hospital of Münster, Münster, Germany (L.K.L., R.D.S., U.N.-G.); Division of Hematology, University Children’s Hospital, Zurich, Switzerland (M.A.); Department of Pediatrics, Hematology/Oncology/BMT, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, and Children’s Hospital, Denver/Aurora, Colo (T.B., N.A.G.,...
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- Karin Kurnik
- From the Israel National Haemophilia Centre, Sheba Medical Centre, Tel-Hashomer, Israel (G.K.); Department of Pediatric Hematology/Oncology, University Hospital of Münster, Münster, Germany (L.K.L., R.D.S., U.N.-G.); Division of Hematology, University Children’s Hospital, Zurich, Switzerland (M.A.); Department of Pediatrics, Hematology/Oncology/BMT, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, and Children’s Hospital, Denver/Aurora, Colo (T.B., N.A.G.,...
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- John K. Lynch
- From the Israel National Haemophilia Centre, Sheba Medical Centre, Tel-Hashomer, Israel (G.K.); Department of Pediatric Hematology/Oncology, University Hospital of Münster, Münster, Germany (L.K.L., R.D.S., U.N.-G.); Division of Hematology, University Children’s Hospital, Zurich, Switzerland (M.A.); Department of Pediatrics, Hematology/Oncology/BMT, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, and Children’s Hospital, Denver/Aurora, Colo (T.B., N.A.G.,...
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- Christoph Male
- From the Israel National Haemophilia Centre, Sheba Medical Centre, Tel-Hashomer, Israel (G.K.); Department of Pediatric Hematology/Oncology, University Hospital of Münster, Münster, Germany (L.K.L., R.D.S., U.N.-G.); Division of Hematology, University Children’s Hospital, Zurich, Switzerland (M.A.); Department of Pediatrics, Hematology/Oncology/BMT, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, and Children’s Hospital, Denver/Aurora, Colo (T.B., N.A.G.,...
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- Marilyn Manco-Johnson
- From the Israel National Haemophilia Centre, Sheba Medical Centre, Tel-Hashomer, Israel (G.K.); Department of Pediatric Hematology/Oncology, University Hospital of Münster, Münster, Germany (L.K.L., R.D.S., U.N.-G.); Division of Hematology, University Children’s Hospital, Zurich, Switzerland (M.A.); Department of Pediatrics, Hematology/Oncology/BMT, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, and Children’s Hospital, Denver/Aurora, Colo (T.B., N.A.G.,...
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- Rolf Mesters
- From the Israel National Haemophilia Centre, Sheba Medical Centre, Tel-Hashomer, Israel (G.K.); Department of Pediatric Hematology/Oncology, University Hospital of Münster, Münster, Germany (L.K.L., R.D.S., U.N.-G.); Division of Hematology, University Children’s Hospital, Zurich, Switzerland (M.A.); Department of Pediatrics, Hematology/Oncology/BMT, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, and Children’s Hospital, Denver/Aurora, Colo (T.B., N.A.G.,...
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- Paul Monagle
- From the Israel National Haemophilia Centre, Sheba Medical Centre, Tel-Hashomer, Israel (G.K.); Department of Pediatric Hematology/Oncology, University Hospital of Münster, Münster, Germany (L.K.L., R.D.S., U.N.-G.); Division of Hematology, University Children’s Hospital, Zurich, Switzerland (M.A.); Department of Pediatrics, Hematology/Oncology/BMT, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, and Children’s Hospital, Denver/Aurora, Colo (T.B., N.A.G.,...
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- C. Heleen van Ommen
- From the Israel National Haemophilia Centre, Sheba Medical Centre, Tel-Hashomer, Israel (G.K.); Department of Pediatric Hematology/Oncology, University Hospital of Münster, Münster, Germany (L.K.L., R.D.S., U.N.-G.); Division of Hematology, University Children’s Hospital, Zurich, Switzerland (M.A.); Department of Pediatrics, Hematology/Oncology/BMT, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, and Children’s Hospital, Denver/Aurora, Colo (T.B., N.A.G.,...
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- Leslie Raffini
- From the Israel National Haemophilia Centre, Sheba Medical Centre, Tel-Hashomer, Israel (G.K.); Department of Pediatric Hematology/Oncology, University Hospital of Münster, Münster, Germany (L.K.L., R.D.S., U.N.-G.); Division of Hematology, University Children’s Hospital, Zurich, Switzerland (M.A.); Department of Pediatrics, Hematology/Oncology/BMT, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, and Children’s Hospital, Denver/Aurora, Colo (T.B., N.A.G.,...
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- Kevin Rostásy
- From the Israel National Haemophilia Centre, Sheba Medical Centre, Tel-Hashomer, Israel (G.K.); Department of Pediatric Hematology/Oncology, University Hospital of Münster, Münster, Germany (L.K.L., R.D.S., U.N.-G.); Division of Hematology, University Children’s Hospital, Zurich, Switzerland (M.A.); Department of Pediatrics, Hematology/Oncology/BMT, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, and Children’s Hospital, Denver/Aurora, Colo (T.B., N.A.G.,...
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- Paolo Simioni
- From the Israel National Haemophilia Centre, Sheba Medical Centre, Tel-Hashomer, Israel (G.K.); Department of Pediatric Hematology/Oncology, University Hospital of Münster, Münster, Germany (L.K.L., R.D.S., U.N.-G.); Division of Hematology, University Children’s Hospital, Zurich, Switzerland (M.A.); Department of Pediatrics, Hematology/Oncology/BMT, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, and Children’s Hospital, Denver/Aurora, Colo (T.B., N.A.G.,...
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- Ronald D. Sträter
- From the Israel National Haemophilia Centre, Sheba Medical Centre, Tel-Hashomer, Israel (G.K.); Department of Pediatric Hematology/Oncology, University Hospital of Münster, Münster, Germany (L.K.L., R.D.S., U.N.-G.); Division of Hematology, University Children’s Hospital, Zurich, Switzerland (M.A.); Department of Pediatrics, Hematology/Oncology/BMT, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, and Children’s Hospital, Denver/Aurora, Colo (T.B., N.A.G.,...
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- Guy Young
- From the Israel National Haemophilia Centre, Sheba Medical Centre, Tel-Hashomer, Israel (G.K.); Department of Pediatric Hematology/Oncology, University Hospital of Münster, Münster, Germany (L.K.L., R.D.S., U.N.-G.); Division of Hematology, University Children’s Hospital, Zurich, Switzerland (M.A.); Department of Pediatrics, Hematology/Oncology/BMT, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, and Children’s Hospital, Denver/Aurora, Colo (T.B., N.A.G.,...
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- Ulrike Nowak-Göttl
- From the Israel National Haemophilia Centre, Sheba Medical Centre, Tel-Hashomer, Israel (G.K.); Department of Pediatric Hematology/Oncology, University Hospital of Münster, Münster, Germany (L.K.L., R.D.S., U.N.-G.); Division of Hematology, University Children’s Hospital, Zurich, Switzerland (M.A.); Department of Pediatrics, Hematology/Oncology/BMT, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, and Children’s Hospital, Denver/Aurora, Colo (T.B., N.A.G.,...
Bibliographic Information
- Other Title
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- A Systematic Review and Meta-Analysis of Observational Studies
Abstract
<jats:p> <jats:bold> <jats:italic>Background—</jats:italic> </jats:bold> The aim of this study was to estimate the impact of thrombophilia on risk of first childhood stroke through a meta-analysis of published observational studies. </jats:p> <jats:p> <jats:bold> <jats:italic>Methods and Results—</jats:italic> </jats:bold> A systematic search of electronic databases (Medline via PubMed, EMBASE, OVID, Web of Science, The Cochrane Library) for studies published from 1970 to 2009 was conducted. Data on year of publication, study design, country of origin, number of patients/control subjects, ethnicity, stroke type (arterial ischemic stroke [AIS], cerebral venous sinus thrombosis [CSVT]) were abstracted. Publication bias indicator and heterogeneity across studies were evaluated, and summary odds ratios (ORs) and 95% confidence intervals (CIs) were calculated with fixed-effects or random-effects models. Twenty-two of 185 references met inclusion criteria. Thus, 1764 patients (arterial ischemic stroke [AIS], 1526; cerebral sinus venous thrombosis [CSVT], 238) and 2799 control subjects (neonate to 18 years of age) were enrolled. No significant heterogeneity was discerned across studies, and no publication bias was detected. A statistically significant association with first stroke was demonstrated for each thrombophilia trait evaluated, with no difference found between AIS and CSVT. Summary ORs (fixed-effects model) were as follows: antithrombin deficiency, 7.06 (95% CI, 2.44 to 22.42); protein C deficiency, 8.76 (95% CI, 4.53 to 16.96); protein S deficiency, 3.20 (95% CI, 1.22 to 8.40), factor V G1691A, 3.26 (95% CI, 2.59 to 4.10); factor II G20210A, 2.43 (95% CI, 1.67 to 3.51); <jats:italic>MTHFR</jats:italic> C677T (AIS), 1.58 (95% CI, 1.20 to 2.08); antiphospholipid antibodies (AIS), 6.95 (95% CI, 3.67 to 13.14); elevated lipoprotein(a), 6.27 (95% CI, 4.52 to 8.69), and combined thrombophilias, 11.86 (95% CI, 5.93 to 23.73). In the 6 exclusively perinatal AIS studies, summary ORs were as follows: factor V, 3.56 (95% CI, 2.29 to 5.53); and factor II, 2.02 (95% CI, 1.02 to 3.99). </jats:p> <jats:p> <jats:bold> <jats:italic>Conclusions—</jats:italic> </jats:bold> The present meta-analysis indicates that thrombophilias serve as risk factors for incident stroke. However, the impact of thrombophilias on outcome and recurrence risk needs to be further investigated. </jats:p>
Journal
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- Circulation
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Circulation 121 (16), 1838-1847, 2010-04-27
Ovid Technologies (Wolters Kluwer Health)
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Details 詳細情報について
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- CRID
- 1361137045015550848
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- ISSN
- 15244539
- 00097322
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- Data Source
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- Crossref