Endoplasmic Reticulum Stress Sensor Protein Kinase R–Like Endoplasmic Reticulum Kinase (PERK) Protects Against Pressure Overload–Induced Heart Failure and Lung Remodeling
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- Xiaoyu Liu
- From the Department of Chinese Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China (X.L., Y.W.); Cardiovascular Division, Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis (X.L., D.K., Z.L., X.X., J.F., H.W., J.H., R.J.B., Y.C.); College of Life Science, University of Chinese Academy of Science, Beijing, China (Z.L.); Department of Biology and The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park (D.R.C.);...
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- Dongmin Kwak
- From the Department of Chinese Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China (X.L., Y.W.); Cardiovascular Division, Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis (X.L., D.K., Z.L., X.X., J.F., H.W., J.H., R.J.B., Y.C.); College of Life Science, University of Chinese Academy of Science, Beijing, China (Z.L.); Department of Biology and The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park (D.R.C.);...
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- Zhongbing Lu
- From the Department of Chinese Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China (X.L., Y.W.); Cardiovascular Division, Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis (X.L., D.K., Z.L., X.X., J.F., H.W., J.H., R.J.B., Y.C.); College of Life Science, University of Chinese Academy of Science, Beijing, China (Z.L.); Department of Biology and The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park (D.R.C.);...
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- Xin Xu
- From the Department of Chinese Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China (X.L., Y.W.); Cardiovascular Division, Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis (X.L., D.K., Z.L., X.X., J.F., H.W., J.H., R.J.B., Y.C.); College of Life Science, University of Chinese Academy of Science, Beijing, China (Z.L.); Department of Biology and The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park (D.R.C.);...
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- John Fassett
- From the Department of Chinese Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China (X.L., Y.W.); Cardiovascular Division, Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis (X.L., D.K., Z.L., X.X., J.F., H.W., J.H., R.J.B., Y.C.); College of Life Science, University of Chinese Academy of Science, Beijing, China (Z.L.); Department of Biology and The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park (D.R.C.);...
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- Huan Wang
- From the Department of Chinese Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China (X.L., Y.W.); Cardiovascular Division, Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis (X.L., D.K., Z.L., X.X., J.F., H.W., J.H., R.J.B., Y.C.); College of Life Science, University of Chinese Academy of Science, Beijing, China (Z.L.); Department of Biology and The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park (D.R.C.);...
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- Yidong Wei
- From the Department of Chinese Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China (X.L., Y.W.); Cardiovascular Division, Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis (X.L., D.K., Z.L., X.X., J.F., H.W., J.H., R.J.B., Y.C.); College of Life Science, University of Chinese Academy of Science, Beijing, China (Z.L.); Department of Biology and The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park (D.R.C.);...
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- Douglas R. Cavener
- From the Department of Chinese Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China (X.L., Y.W.); Cardiovascular Division, Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis (X.L., D.K., Z.L., X.X., J.F., H.W., J.H., R.J.B., Y.C.); College of Life Science, University of Chinese Academy of Science, Beijing, China (Z.L.); Department of Biology and The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park (D.R.C.);...
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- Xinli Hu
- From the Department of Chinese Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China (X.L., Y.W.); Cardiovascular Division, Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis (X.L., D.K., Z.L., X.X., J.F., H.W., J.H., R.J.B., Y.C.); College of Life Science, University of Chinese Academy of Science, Beijing, China (Z.L.); Department of Biology and The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park (D.R.C.);...
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- Jennifer Hall
- From the Department of Chinese Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China (X.L., Y.W.); Cardiovascular Division, Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis (X.L., D.K., Z.L., X.X., J.F., H.W., J.H., R.J.B., Y.C.); College of Life Science, University of Chinese Academy of Science, Beijing, China (Z.L.); Department of Biology and The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park (D.R.C.);...
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- Robert J. Bache
- From the Department of Chinese Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China (X.L., Y.W.); Cardiovascular Division, Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis (X.L., D.K., Z.L., X.X., J.F., H.W., J.H., R.J.B., Y.C.); College of Life Science, University of Chinese Academy of Science, Beijing, China (Z.L.); Department of Biology and The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park (D.R.C.);...
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- Yingjie Chen
- From the Department of Chinese Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China (X.L., Y.W.); Cardiovascular Division, Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis (X.L., D.K., Z.L., X.X., J.F., H.W., J.H., R.J.B., Y.C.); College of Life Science, University of Chinese Academy of Science, Beijing, China (Z.L.); Department of Biology and The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park (D.R.C.);...
書誌事項
- 公開日
- 2014-10
- DOI
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- 10.1161/hypertensionaha.114.03811
- 公開者
- Ovid Technologies (Wolters Kluwer Health)
この論文をさがす
説明
<jats:p> Studies have reported that development of congestive heart failure is associated with increased endoplasmic reticulum stress. Double stranded RNA-activated protein kinase R–like endoplasmic reticulum kinase (PERK) is a major transducer of the endoplasmic reticulum stress response and directly phosphorylates eukaryotic initiation factor 2α, resulting in translational attenuation. However, the physiological effect of PERK on congestive heart failure development is unknown. To study the effect of PERK on ventricular structure and function, we generated inducible cardiac-specific PERK knockout mice. Under unstressed conditions, cardiac PERK knockout had no effect on left ventricular mass, or its ratio to body weight, cardiomyocyte size, fibrosis, or left ventricular function. However, in response to chronic transverse aortic constriction, PERK knockout mice exhibited decreased ejection fraction, increased left ventricular fibrosis, enhanced cardiomyocyte apoptosis, and exacerbated lung remodeling in comparison with wild-type mice. PERK knockout also dramatically attenuated cardiac sarcoplasmic reticulum Ca <jats:sup>2+</jats:sup> -ATPase expression in response to aortic constriction. Our findings suggest that PERK is required to protect the heart from pressure overload–induced congestive heart failure. </jats:p>
収録刊行物
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- Hypertension
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Hypertension 64 (4), 738-744, 2014-10
Ovid Technologies (Wolters Kluwer Health)