The Netrin-1/DCC guidance system: dopamine pathway maturation and psychiatric disorders emerging in adolescence

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<jats:title>Abstract</jats:title> <jats:p>Axon guidance molecules direct growing axons toward their targets, assembling the intricate wiring of the nervous system. One of these molecules, Netrin-1, and its receptor, DCC (deleted in colorectal cancer), has profound effects, in laboratory animals, on the adolescent expansion of mesocorticolimbic pathways, particularly dopamine. Now, a rapidly growing literature suggests that (1) these same alterations could occur in humans, and (2) genetic variants in <jats:italic>Netrin-1</jats:italic> and <jats:italic>DCC</jats:italic> are associated with depression, schizophrenia, and substance use. Together, these findings provide compelling evidence that <jats:italic>Netrin-1</jats:italic> and <jats:italic>DCC</jats:italic> influence mesocorticolimbic-related psychopathological states that emerge during adolescence.</jats:p>

Journal

  • Molecular Psychiatry

    Molecular Psychiatry 25 (2), 297-307, 2019-10-28

    Springer Science and Business Media LLC

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