Neurofunctional topography of the human hippocampus

  • Jennifer L. Robinson
    Department of Psychology Auburn University 226 Thach Hall Auburn Alabama
  • Daniel S. Barron
    Yale University School of Medicine New Haven Connecticut
  • Lauren A. J. Kirby
    Department of Psychology Auburn University 226 Thach Hall Auburn Alabama
  • Katherine L. Bottenhorn
    Department of Psychology Auburn University 226 Thach Hall Auburn Alabama
  • Ashley C. Hill
    Department of Psychology Auburn University 226 Thach Hall Auburn Alabama
  • Jerry E. Murphy
    Department of Psychology Auburn University 226 Thach Hall Auburn Alabama
  • Jeffrey S. Katz
    Department of Psychology Auburn University 226 Thach Hall Auburn Alabama
  • Nouha Salibi
    Department of Electrical and Computer Engineering Auburn University, Auburn University Magnetic Resonance Imaging Research Center 560 Devall Drive Auburn Alabama
  • Simon B. Eickhoff
    Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf Germany
  • Peter T. Fox
    Research Imaging Institute, University of Texas Health Science Center at San Antonio San Antonio Texas

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<jats:title>Abstract</jats:title><jats:p>Much of what was assumed about the functional topography of the hippocampus was derived from a single case study over half a century ago. Given advances in the imaging sciences, a new era of discovery is underway, with potential to transform the understanding of healthy processing as well as the ability to treat disorders. Coactivation‐based parcellation, a meta‐analytic approach, and ultra‐high field, high‐resolution functional and structural neuroimaging to characterize the neurofunctional topography of the hippocampus was employed. Data revealed strong support for an evolutionarily preserved topography along the long‐axis. Specifically, the left hippocampus was segmented into three distinct clusters: an emotional processing cluster supported by structural and functional connectivity to the amygdala and parahippocampal gyrus, a cognitive operations cluster, with functional connectivity to the anterior cingulate and inferior frontal gyrus, and a posterior perceptual cluster with distinct structural connectivity patterns to the occipital lobe coupled with functional connectivity to the precuneus and angular gyrus. The right hippocampal segmentation was more ambiguous, with plausible 2‐ and 5‐cluster solutions. Segmentations shared connectivity with brain regions known to support the correlated processes. This represented the first neurofunctional topographic model of the hippocampus using a robust, bias‐free, multimodal approach. <jats:italic>Hum Brain Mapp 36:5018–5037, 2015</jats:italic>. © <jats:bold>2015 Wiley Periodicals, Inc.</jats:bold></jats:p>

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