<i>De novo</i> lipogenesis in the liver in health and disease: more than just a shunting yard for glucose
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- Francis W. B. Sanders
- MRC Human Nutrition Research, Elsie Widdowson Laboratory 120 Fulbourn Road Cambridge CB1 9NL U.K.
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- Julian L. Griffin
- MRC Human Nutrition Research, Elsie Widdowson Laboratory 120 Fulbourn Road Cambridge CB1 9NL U.K.
抄録
<jats:title>ABSTRACT</jats:title><jats:p>Hepatic <jats:italic>de novo</jats:italic> lipogenesis (<jats:styled-content style="fixed-case">DNL</jats:styled-content>) is the biochemical process of synthesising fatty acids from acetyl‐<jats:styled-content style="fixed-case">CoA</jats:styled-content> subunits that are produced from a number of different pathways within the cell, most commonly carbohydrate catabolism. In addition to glucose which most commonly supplies carbon units for <jats:styled-content style="fixed-case">DNL</jats:styled-content>, fructose is also a profoundly lipogenic substrate that can drive <jats:styled-content style="fixed-case">DNL</jats:styled-content>, important when considering the increasing use of fructose in corn syrup as a sweetener. In the context of disease, <jats:styled-content style="fixed-case">DNL</jats:styled-content> is thought to contribute to the pathogenesis of non‐alcoholic fatty liver disease, a common condition often associated with the metabolic syndrome and consequent insulin resistance. Whether <jats:styled-content style="fixed-case">DNL</jats:styled-content> plays a significant role in the pathogenesis of insulin resistance is yet to be fully elucidated, but it may be that the prevalent products of this synthetic process induce some aspect of hepatic insulin resistance.</jats:p>
収録刊行物
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- Biological Reviews
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Biological Reviews 91 (2), 452-468, 2015-03-04
Wiley