Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice

DOI Web Site 被引用文献66件
  • Per Lindahl
    P. Lindahl, P. Levéen, C. Betsholtz, Department of Medical Biochemistry, University of Göteborg, Medicinaregatan 9A, S-413 90 Göteborg, Sweden.
  • Bengt R. Johansson
    P. Lindahl, P. Levéen, C. Betsholtz, Department of Medical Biochemistry, University of Göteborg, Medicinaregatan 9A, S-413 90 Göteborg, Sweden.
  • Per Levéen
    P. Lindahl, P. Levéen, C. Betsholtz, Department of Medical Biochemistry, University of Göteborg, Medicinaregatan 9A, S-413 90 Göteborg, Sweden.
  • Christer Betsholtz
    P. Lindahl, P. Levéen, C. Betsholtz, Department of Medical Biochemistry, University of Göteborg, Medicinaregatan 9A, S-413 90 Göteborg, Sweden.

書誌事項

公開日
1997-07-11
DOI
  • 10.1126/science.277.5323.242
公開者
American Association for the Advancement of Science (AAAS)

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説明

<jats:p>Platelet-derived growth factor (PDGF)–B–deficient mouse embryos were found to lack microvascular pericytes, which normally form part of the capillary wall, and they developed numerous capillary microaneurysms that ruptured at late gestation. Endothelial cells of the sprouting capillaries in the mutant mice appeared to be unable to attract PDGF-Rβ–positive pericyte progenitor cells. Pericytes may contribute to the mechanical stability of the capillary wall. Comparisons made between PDGF null mouse phenotypes suggest a general role for PDGFs in the development of myofibroblasts.</jats:p>

収録刊行物

  • Science

    Science 277 (5323), 242-245, 1997-07-11

    American Association for the Advancement of Science (AAAS)

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