Apigenin inhibits VEGF and HIF‐1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways

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  • Jing Fang
    The Mary Babb Randolph Cancer Center Department of Microbiology Immunology and Cell Biology West Virginia University Morgantown West Virginia USA
  • Chang Xia
    The Mary Babb Randolph Cancer Center Department of Microbiology Immunology and Cell Biology West Virginia University Morgantown West Virginia USA
  • Zongxian Cao
    The Mary Babb Randolph Cancer Center Department of Microbiology Immunology and Cell Biology West Virginia University Morgantown West Virginia USA
  • Jenny Z. Zheng
    The Mary Babb Randolph Cancer Center Department of Microbiology Immunology and Cell Biology West Virginia University Morgantown West Virginia USA
  • Eddie Reed
    The Mary Babb Randolph Cancer Center Department of Microbiology Immunology and Cell Biology West Virginia University Morgantown West Virginia USA
  • Bing-Hua Jiang
    The Mary Babb Randolph Cancer Center Department of Microbiology Immunology and Cell Biology West Virginia University Morgantown West Virginia USA

書誌事項

公開日
2005-03
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1096/fj.04-2175com
公開者
Wiley

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<jats:title>ABSTRACT</jats:title> <jats:p> Apigenin is a nontoxic dietary flavonoid that has been shown to possess anti‐tumor properties and therefore poses special interest for the development of a novel chemopreventive and/or chemotherapeutic agent for cancer. Ovarian cancer is one of the most common causes of cancer death among women. Here we demonstrate that apigenin inhibits expression of vascular endothelial growth factor (VEGF) in human ovarian cancer cells. VEGF plays an important role in tumor angiogenesis and growth. We found that apigenin inhibited VEGF expression at the transcriptional level through expression of hypoxia‐inducible factor 1α (HIF‐1α). Apigenin inhibited expression of HIF‐1α and VEGF via the PI3K/AKT/p70S6K1 and HDM2/ p53 pathways. Apigenin inhibited tube formation in vitro by endothelial cells. These findings reveal a novel role of apigenin in inhibiting HIF‐1 and VEGF expression that is important for tumor angiogenesis and growth, identifying new signaling molecules that mediate this regulation.—Fang, J., Xia, C., Cao, Z., Zheng, J. Z., Reed, E., Jiang, B.‐H. Apigenin inhibits VEGF and HIF‐1 expression via PI3K/AKT/p70S6K1 and HDM2/ p53 pathways. <jats:italic>FASEB J.</jats:italic> 19, 342–353 (2005) </jats:p>

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