Evaluating Human Embryonic Germ Cells: Concord and Conflict as Pluripotent Stem Cells

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  • Lee Turnpenny
    Early Human Development and Stem Cells Group, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
  • Cosma M. Spalluto
    Early Human Development and Stem Cells Group, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
  • Rebecca M. Perrett
    Early Human Development and Stem Cells Group, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
  • Marie O'Shea
    Early Human Development and Stem Cells Group, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
  • Karen Piper Hanley
    Early Human Development and Stem Cells Group, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
  • Iain T. Cameron
    Early Human Development and Stem Cells Group, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
  • David I. Wilson
    Early Human Development and Stem Cells Group, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
  • Neil A. Hanley
    Early Human Development and Stem Cells Group, University of Southampton, Southampton General Hospital, Southampton, United Kingdom

Description

<jats:title>Abstract</jats:title><jats:p>The realization of cell replacement therapy derived from human pluripotent stem cells requires full knowledge of the starting cell types as well as their differentiated progeny. Alongside embryonic stem cells, embryonic germ cells (EGCs) are an alternative source of pluripotent stem cell. Since 1998, four groups have described the derivation of human EGCs. This review analyzes the progress on derivation, culture, and differentiation, drawing comparison with other pluripotent stem cell populations.</jats:p>

Journal

  • Stem Cells

    Stem Cells 24 (2), 212-220, 2005-09-06

    Oxford University Press (OUP)

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