Biologically Active Aspidofractinine Alkaloids from <i>Kopsia singapurensis</i>

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  • G. Subramaniam
    Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia, The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan, Faculty of Pharmacy, Iwaki Meisei University, 5-5-1, Chuodai Iino, Iwaki, Fukushima 970-8551, Japan, and Temko Corporation, 4-27-4 Honcho, Nakano-ku, Tokyo 164, Japan
  • Osamu Hiraku
    Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia, The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan, Faculty of Pharmacy, Iwaki Meisei University, 5-5-1, Chuodai Iino, Iwaki, Fukushima 970-8551, Japan, and Temko Corporation, 4-27-4 Honcho, Nakano-ku, Tokyo 164, Japan
  • Masahiko Hayashi
    Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia, The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan, Faculty of Pharmacy, Iwaki Meisei University, 5-5-1, Chuodai Iino, Iwaki, Fukushima 970-8551, Japan, and Temko Corporation, 4-27-4 Honcho, Nakano-ku, Tokyo 164, Japan
  • Takashi Koyano
    Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia, The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan, Faculty of Pharmacy, Iwaki Meisei University, 5-5-1, Chuodai Iino, Iwaki, Fukushima 970-8551, Japan, and Temko Corporation, 4-27-4 Honcho, Nakano-ku, Tokyo 164, Japan
  • Kanki Komiyama
    Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia, The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan, Faculty of Pharmacy, Iwaki Meisei University, 5-5-1, Chuodai Iino, Iwaki, Fukushima 970-8551, Japan, and Temko Corporation, 4-27-4 Honcho, Nakano-ku, Tokyo 164, Japan
  • Toh-Seok Kam
    Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia, The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan, Faculty of Pharmacy, Iwaki Meisei University, 5-5-1, Chuodai Iino, Iwaki, Fukushima 970-8551, Japan, and Temko Corporation, 4-27-4 Honcho, Nakano-ku, Tokyo 164, Japan

書誌事項

公開日
2007-12-14
DOI
  • 10.1021/np070401t
公開者
American Chemical Society (ACS)

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説明

Ten new indole alkaloids of the aspidofractinine type, in addition to several recently reported indole alkaloids and 20 other known alkaloids, were obtained from the leaf and stem-bark extract of the Malayan Kopsia singapurensis, viz., kopsimalines A-E (1-5), kopsinicine (6), kopsofinone (7), and kopsiloscines H-J (8-10). The structures of these alkaloids were determined using NMR and MS analysis. Kopsimalines A (1), B (2), C (3), D (4), and E (5) and kopsiloscine J (10) were found to reverse multidrug-resistance in vincristine-resistant KB cells, with 1 showing the highest potency.

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