Effects of rectal administration of taurocholic acid on glucagon‐like peptide‐1 and peptide <scp>YY</scp> secretion in healthy humans

DOI Web Site Web Site 被引用文献3件
  • T. Wu
    Discipline of Medicine University of Adelaide, Royal Adelaide Hospital Adelaide Australia
  • M. J. Bound
    Discipline of Medicine University of Adelaide, Royal Adelaide Hospital Adelaide Australia
  • S. D. Standfield
    Discipline of Medicine University of Adelaide, Royal Adelaide Hospital Adelaide Australia
  • B. Gedulin
    Satiogen Pharmaceuticals Inc. San Diego CA USA
  • K. L. Jones
    Discipline of Medicine University of Adelaide, Royal Adelaide Hospital Adelaide Australia
  • M. Horowitz
    Discipline of Medicine University of Adelaide, Royal Adelaide Hospital Adelaide Australia
  • C. K. Rayner
    Discipline of Medicine University of Adelaide, Royal Adelaide Hospital Adelaide Australia

説明

<jats:p>Glucagon‐like peptide‐1 (<jats:styled-content style="fixed-case">GLP</jats:styled-content>‐1) and peptide <jats:styled-content style="fixed-case">YY</jats:styled-content> (<jats:styled-content style="fixed-case">PYY</jats:styled-content>), secreted by enteroendocrine L‐cells located most densely in the colon and rectum, are of fundamental importance in blood glucose and appetite regulation. In animal models, colonic administration of bile acids can stimulate <jats:styled-content style="fixed-case">GLP</jats:styled-content>‐1 and <jats:styled-content style="fixed-case">PYY</jats:styled-content> by <jats:styled-content style="fixed-case">TGR5</jats:styled-content> receptor activation. We evaluated the effects of taurocholic acid (<jats:styled-content style="fixed-case">TCA</jats:styled-content>), administered as an enema, on plasma <jats:styled-content style="fixed-case">GLP</jats:styled-content>‐1 and <jats:styled-content style="fixed-case">PYY</jats:styled-content>, as well as gastrointestinal sensations in 10 healthy male subjects, and observed that rectal administration of <jats:styled-content style="fixed-case">TCA</jats:styled-content> promptly stimulated secretion of both <jats:styled-content style="fixed-case">GLP</jats:styled-content>‐1 and <jats:styled-content style="fixed-case">PYY</jats:styled-content>, and increased fullness, in a dose‐dependent manner. These observations confirm that topical application of bile acids to the distal gut may have potential for the management of type 2 diabetes and obesity.</jats:p>

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