The RecQ DNA Helicases in DNA Repair

DOI Web Site 7 Citations
  • Kara A. Bernstein
    Columbia University Medical Center, Department of Genetics & Development, New York, New York 10032;,
  • Serge Gangloff
    CEA, DSV, iRCM, SIGRR, LERA, Fontenay-aux-Roses F-92265, France;
  • Rodney Rothstein
    Columbia University Medical Center, Department of Genetics & Development, New York, New York 10032;,

Abstract

<jats:p>The RecQ helicases are conserved from bacteria to humans and play a critical role in genome stability. In humans, loss of RecQ gene function is associated with cancer predisposition and/or premature aging. Recent experiments have shown that the RecQ helicases function during distinct steps during DNA repair; DNA end resection, displacement-loop (D-loop) processing, branch migration, and resolution of double Holliday junctions (dHJs). RecQ function in these different processing steps has important implications for its role in repair of double-strand breaks (DSBs) that occur during DNA replication and meiosis, as well as at specific genomic loci such as telomeres.</jats:p>

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