Dynamic changes in bone metabolism in the rat temporomandibular joint after molar extraction using bone scintigraphy

DOI Web Site Web Site PubMed 被引用文献5件

書誌事項

公開日
2009-07-14
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1111/j.1600-0722.2009.00635.x
公開者
Wiley

この論文をさがす

説明

<jats:p>Functional adaptation with reformation of bone tissue structure occurs after changes in mechanical stress distribution. To examine how occlusal changes affect the dynamics of bone metabolism in the mandibular condyle, bone scintigraphy of rat condyles was taken using <jats:sup>99m</jats:sup>technetium‐methylene‐diphosphonate (<jats:sup>99m</jats:sup>Tc‐MDP) after extraction of maxillary molars resulting in unilateral loss of occlusal support. Accumulation of <jats:sup>99m</jats:sup>Tc‐MDP was significantly higher in the condyles on the extracted side than on the intact side 3 d after molar extraction. In addition, bone mineral density (BMD) and osteoprotegerin expression in extracted‐side condyles were significantly increased while osteoclast numbers were significantly decreased when compared with intact‐side condyles. These differences were not detected 28 d after molar extraction. These findings suggest that occlusal change transiently results in changes in the dynamics of bone metabolism at the mandibular condyles through the downregulation of osteoclastogenesis. These changes may be involved in functional adaptation of the temporomandibular joint.</jats:p>

収録刊行物

被引用文献 (5)*注記

もっと見る

キーワード

問題の指摘

ページトップへ