Quantitative MRI of articular cartilage and its clinical applications

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  • Xiaojuan Li
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging University of California San Francisco California USA
  • Sharmila Majumdar
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging University of California San Francisco California USA

Bibliographic Information

Published
2013-10-02
Rights Information
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1002/jmri.24313
Publisher
Wiley

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<jats:p>Cartilage is one of the most essential tissues for healthy joint function and is compromised in degenerative and traumatic joint diseases. There have been tremendous advances during the past decade using quantitative MRI techniques as a noninvasive tool for evaluating cartilage, with a focus on assessing cartilage degeneration during osteoarthritis (OA). In this review, after a brief overview of cartilage composition and degeneration, we discuss techniques that grade and quantify morphologic changes as well as the techniques that quantify changes in the extracellular matrix. The basic principles, in vivo applications, advantages, and challenges for each technique are discussed. Recent studies using the OA Initiative (OAI) data are also summarized. Quantitative MRI provides noninvasive measures of cartilage degeneration at the earliest stages of joint degeneration, which is essential for efforts toward prevention and early intervention in OA. J. Magn. Reson. Imaging 2013;38:991–1008. © 2013 Wiley Periodicals, Inc.</jats:p>

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