Drug-Induced Changes in the Liver Endoplasmic Reticulum: Association with Drug-Metabolizing Enzymes

DOI Web Site 被引用文献3件
  • H. Remmer
    Department of Pharmacology and Institute for Electronmicroscopy, Freien Universiät, Berlin-Dahlem, Germany
  • H. J. Merker
    Department of Pharmacology and Institute for Electronmicroscopy, Freien Universiät, Berlin-Dahlem, Germany

書誌事項

公開日
1963-12-27
DOI
  • 10.1126/science.142.3600.1657
公開者
American Association for the Advancement of Science (AAAS)

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説明

<jats:p>The cellular changes which lead to the increase of drug-metabolizing enzymes following drug administration are explained by correlating new biochemical data with previously reported electron microscopic and pharmacologic observations. Repeated administration of phenobarbital and several other drugs results in a quantitative increase of the smooth endoplasmic reticulum of the liver cell. The marked increase in drug-metabolizing enzymes is found to occur in this enlarged smooth membrane fraction of the endoplasmic reticulum.</jats:p>

収録刊行物

  • Science

    Science 142 (3600), 1657-1658, 1963-12-27

    American Association for the Advancement of Science (AAAS)

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