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- Fatemeh Moradkhani
- Department of Toxicology and Pharmacology, Faculty of Pharmacy Tehran University of Medical Sciences Tehran Iran
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- Milad Moloudizargari
- Department of Immunology, School of Medicine, Student Research Committee Shahid Beheshti University of Medical Sciences Tehran Iran
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- Marjan Fallah
- Department of Toxicology and Pharmacology, Faculty of Pharmacy Mazandaran University of Medical Sciences Sari Iran
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- Narjes Asghari
- Department of Biology, Damghan Branch Islamic Azad University Damghan Iran
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- Heidar Heidari Khoei
- Department of Stem Cells and Developmental Biology, Cell Science Research Center Royan Institute for Stem Cell Biology and Technology, ACECR Tehran Iran
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- Mohammad Hossein Asghari
- Department of Pharmacology and Toxicology, School of Medicine Babol University of Medical Sciences Babol Iran
書誌事項
- 公開日
- 2019-07-04
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1002/jcp.29036
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p>Melatonin is a ubiquitous indole amine that plays a fundamental role in the regulation of the biological rhythm. Disrupted circadian rhythm alters the expression of clock genes and deregulates oncogenes, which finally promote tumor development and progression. An evidence supporting this notion is the higher risk of developing malignancies among night shift workers. Circadian secretion of the pineal hormone also synchronizes the immune system via a reciprocal association that exists between the immune system and melatonin. Immune cells are capable of melatonin biosynthesis in addition to the expression of its receptors. Melatonin induces big changes in different immune cell proportions, enhances their viability and improves immune cell metabolism in the tumor microenvironment. These effects might be directly mediated by melatonin receptors or indirectly through alterations in hormonal and cytokine release. Moreover, melatonin induces apoptosis in tumor cells via the intrinsic and extrinsic pathways of apoptosis, while it protectsthe immune cells. In general, melatonin has a profound impact on immune cell trafficking, cytokine production and apoptosis induction in malignant cells. On such a basis, using melatonin and resynchronization of sleep cycle may have potential implications in immune function enhancement against malignancies, which will be the focus of the present paper.</jats:p>
収録刊行物
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- Journal of Cellular Physiology
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Journal of Cellular Physiology 235 (2), 745-757, 2019-07-04
Wiley
