Organocatalytic Enantioselective Alkylation of Pyrazol‐3‐ones with Isatin‐Derived Ketimines: Stereocontrolled Construction of Vicinal Tetrasubstituted Stereocenters

Fares Ibrahim Amr, Carlos Vila, Gonzalo Blay, M. Carmen Muñoz, José R. Pedro

doi:10.1002/adsc.201600036

Organocatalytic Enantioselective Alkylation of Pyrazol‐3‐ones with Isatin‐Derived Ketimines: Stereocontrolled Construction of Vicinal Tetrasubstituted Stereocenters

DOI Web Site Web Site 被引用文献2件

書誌事項

公開日: 2016-04-24

権利情報

http://onlinelibrary.wiley.com/termsAndConditions#vor

DOI

10.1002/adsc.201600036

公開者: Wiley

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説明

<jats:title>Abstract</jats:title><jats:p>A quinine‐derived thiourea catalysed the enantioselective addition of 4‐substituted pyrazolones to isatin‐derived ketimines, providing a variety of aminooxindole‐pyrazolone adducts containing congested vicinal tetrasubstituted stereocentres with excellent outcomes (up to 98% yield, >20:1 <jats:italic>dr</jats:italic> and 98% <jats:italic>ee</jats:italic>).</jats:p><jats:p><jats:boxed-text content-type="graphic" position="anchor"><jats:graphic xmlns:xlink="http://www.w3.org/1999/xlink" mimetype="image/gif" position="anchor" specific-use="enlarged-web-image" xlink:href="graphic/mcontent.gif"><jats:alt-text>magnified image</jats:alt-text></jats:graphic></jats:boxed-text></jats:p>