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- Jin Young Kang
- Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejon 305-701, Korea;
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- Jie-Oh Lee
- Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejon 305-701, Korea;
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説明
<jats:p>Innate immune receptors respond to common structural patterns in microbial molecules and are called pattern recognition receptors. Toll-like receptors (TLRs) play critical roles in the innate immune system by recognizing microbial lipids, carbohydrates, nucleic acids, and proteins. Precise definition of the ligand “pattern” of TLRs has been difficult to determine primarily owing to a lack of high-resolution structures. Recently, the structures of several TLR-ligand complexes and the intracellular signaling domains have been determined by X-ray crystallography. This new structural information, combined with extensive biochemical and immunological data accumulated over decades, sheds new light on ligand-recognition and -activation mechanisms. In this review, we summarize the TLR structures and discuss proposed ligand-recognition and -activation mechanisms.</jats:p>
収録刊行物
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- Annual Review of Biochemistry
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Annual Review of Biochemistry 80 (1), 917-941, 2011-07-07
Annual Reviews
