Disposition and metabolism of the flavonoid chrysin in normal volunteers
書誌事項
- 公開日
- 2001-02
- 権利情報
-
- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
-
- 10.1111/j.1365-2125.2001.01317.x
- 公開者
- Wiley
この論文をさがす
説明
<jats:p><jats:bold>Aims </jats:bold> To describe the oral disposition of the dietary flavonoid chrysin in healthy volunteers.</jats:p><jats:p><jats:bold>Methods </jats:bold> Oral 400 mg doses of chrysin were administered to seven subjects. Chrysin and metabolites were assayed in plasma, urine and faeces by h.p.l.c.</jats:p><jats:p><jats:bold>Results </jats:bold> Peak plasma chrysin concentrations were only 3–16 ng ml<jats:sup>−1</jats:sup> with AUCs of 5–193 ng ml<jats:sup>−1</jats:sup> h. Plasma chrysin sulphate concentrations were 30‐fold higher (AUC 450–4220 ng ml<jats:sup>−1</jats:sup> h). In urine, chrysin and chrysin glucuronide accounted for 0.2–3.1 mg and 2–26 mg, respectively. Most of the dose appeared in faeces as chrysin. Parallel experiments in rats showed high bile concentrations of chrysin conjugates.</jats:p><jats:p><jats:bold>Conclusions </jats:bold> These findings, together with previous data using Caco‐2 cells, suggest that chrysin has low oral bioavailability, mainly due to extensive metabolism and efflux of metabolites back into the intestine for hydrolysis and faecal elimination.</jats:p>
収録刊行物
-
- British Journal of Clinical Pharmacology
-
British Journal of Clinical Pharmacology 51 (2), 143-146, 2001-02
Wiley