The Concise Guide to<scp>PHARMACOLOGY</scp>2013/14: Ligand‐Gated Ion Channels

<jats:title>Abstract</jats:title><jats:p>The Concise Guide to<jats:styled-content style="fixed-case">PHARMACOLOGY</jats:styled-content>2013/14 provides concise overviews of the key properties of over 2000 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://www.guidetopharmacology.org">www.guidetopharmacology.org</jats:ext-link>), which provides more detailed views of target and ligand properties. The full contents can be found at<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://onlinelibrary.wiley.com/doi/10.1111/bph.12444/full">http://onlinelibrary.wiley.com/doi/10.1111/bph.12444/full</jats:ext-link>.</jats:p><jats:p>Ligand‐gated ion channels are one of the seven major pharmacological targets into which the Guide is divided, with the others being<jats:styled-content style="fixed-case">G</jats:styled-content>protein‐coupled receptors, ion channels, catalytic receptors, nuclear hormone receptors, transporters and enzymes. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. A new landscape format has easy to use tables comparing related targets.</jats:p><jats:p>It is a condensed version of material contemporary to late 2013, which is presented in greater detail and constantly updated on the website<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://www.guidetopharmacology.org">www.guidetopharmacology.org</jats:ext-link>, superseding data presented in previous Guides to Receptors and Channels. It is produced in conjunction with<jats:styled-content style="fixed-case">NC‐IUPHAR</jats:styled-content>and provides the official<jats:styled-content style="fixed-case">IUPHAR</jats:styled-content>classification and nomenclature for human drug targets, where appropriate. It consolidates information previously curated and displayed separately in<jats:styled-content style="fixed-case">IUPHAR‐DB</jats:styled-content>and the Guide to Receptors and Channels, providing a permanent, citable, point‐in‐time record that will survive database updates.</jats:p>