EBV-positive large B-cell lymphomas in young patients: a nodal lymphoma with evidence for a tolerogenic immune environment
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- Alina Nicolae
- Hematopathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, MD;
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- Stefania Pittaluga
- Hematopathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, MD;
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- Shahed Abdullah
- Hematopathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, MD;
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- Seth M. Steinberg
- Biostatistics and Data Management Section, Office of the Clinical Director, Center for Cancer Research, National Cancer Institute, Bethesda, MD; and
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- Thu Anh Pham
- Molecular Diagnostics Unit, Laboratory of Pathology, National Cancer Institute, Bethesda, MD
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- Theresa Davies-Hill
- Hematopathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, MD;
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- Liqiang Xi
- Molecular Diagnostics Unit, Laboratory of Pathology, National Cancer Institute, Bethesda, MD
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- Mark Raffeld
- Molecular Diagnostics Unit, Laboratory of Pathology, National Cancer Institute, Bethesda, MD
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- Elaine S. Jaffe
- Hematopathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, MD;
書誌事項
- 公開日
- 2015-08-13
- DOI
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- 10.1182/blood-2015-02-630632
- 公開者
- American Society of Hematology
この論文をさがす
説明
<jats:title>Key Points</jats:title> <jats:p>EBV+ LBCLs in young patients resemble those seen in the elderly, but usually have a good outcome. Tumor cells exhibit PD-L1 expression, with high indoleamine 2,3-dioxygenase–positive cell content, indications of a tolerogenic immune state.</jats:p>
収録刊行物
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- Blood
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Blood 126 (7), 863-872, 2015-08-13
American Society of Hematology