CD25 Blockade Depletes and Selectively Reprograms Regulatory T Cells in Concert with Immunotherapy in Cancer Patients
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- Andrew J. Rech
- Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
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- Rosemarie Mick
- Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
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- Sunil Martin
- Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
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- Adri Recio
- Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
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- Nicole A. Aqui
- Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
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- Daniel J. Powell
- Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
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- Theresa A. Colligon
- Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
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- Jennifer A. Trosko
- Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
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- Leah I. Leinbach
- Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
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- Charles H. Pletcher
- Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
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- Carol K. Tweed
- Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
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- Angela DeMichele
- Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
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- Kevin R. Fox
- Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
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- Susan M. Domchek
- Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
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- James L. Riley
- Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
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- Robert H. Vonderheide
- Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
説明
<jats:p> CD25 monoclonal antibody therapy rapidly and durably depletes T <jats:sub>regs</jats:sub> in cancer patients through a mechanism consistent with reprogramming. </jats:p>
収録刊行物
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- Science Translational Medicine
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Science Translational Medicine 4 (134), 134ra62-, 2012-05-16
American Association for the Advancement of Science (AAAS)