Assessing Cell and Organ Senescence Biomarkers

DOI Web Site 2 Citations
  • Bruno Bernardes de Jesus
    From the Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Madrid, Spain.
  • Maria A. Blasco
    From the Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Madrid, Spain.

Abstract

<jats:p>A major goal in cancer and aging research is to discriminate the biochemical modifications that happen locally that could account for the healthiness or malignancy of tissues. Senescence is one general antiproliferative cellular process that acts as a strong barrier for cancer progression, playing a crucial role in aging. Here, we focus on the current methods to assess cellular senescence, discriminating the advantages and disadvantages of several senescence biomarkers.</jats:p>

Journal

  • Circulation Research

    Circulation Research 111 (1), 97-109, 2012-06-22

    Ovid Technologies (Wolters Kluwer Health)

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